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Finals Flash Cards 🩺 > Respiratory > Flashcards

Respiratory Flashcards

1
Q

What are the features of moderate acute asthma?

A
  • Increasing symptoms
  • Peak flow >50-75% best or predicted
  • No features of acute severe asthma
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2
Q

What are the features of severe acute asthma?

A

Any one of the following:
- Peak flow 33-50% best or predicted;
- Respiratory rate ≥ 25/min;
- Heart rate ≥ 110/min;
- Inability to complete sentences in one breath.

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3
Q

What are the features of life-threatening acute asthma?

A

Any one of the following in a patient with severe asthma:

  • Peak flow < 33% best or predicted;
  • Arterial oxygen saturation (SpO2) < 92%;
  • Partial arterial pressure of oxygen (PaO2) < 8 kPa;
  • Normal partial arterial pressure of carbon dioxide (PaCO2) (4.6–6.0 kPa);
  • Silent chest;
  • Cyanosis;
  • Poor respiratory effort;
  • Arrhythmia;
  • Exhaustion;
  • Altered conscious level;
  • Hypotension.
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4
Q

Which type of lung fibrosis typically affects the lower zones?

A

Idiopathic pulmonary fibrosis
Most connective tissue disorders (e.g. SLE)
Drug induced: Amiodarone, Bleomycin, Methotrexate
Asbestosis

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5
Q

Which types of lung fibrosis typically affect the upper zones?

A
  • Hypersensitivity pneumonitis (also known as extrinsic allergic alveolitis)
  • Coal worker’s pneumoconiosis/progressive massive fibrosis
  • Silicosis
  • Sarcoidosis
  • Ankylosing spondylitis (rare)
  • Histiocytosis
  • Tuberculosis
  • Radiation-induced pulmonary fibrosis
    may develop following radiotherapy for breast or lung cancer
    typically seen between 6 and 12 months following completion of radiotherapy course
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6
Q

What is the most common type of lung cancer?

A

Adenocarcinoma (non small cell carcinoma)

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7
Q

List some risk factors of lung cancer?

A
  • Smoking
  • Radiation exposure
  • HIV
  • Asbestos exposure
  • Welding fumes
  • Coal
  • Organ transplant
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8
Q

What is the mode of transmission for TB?

A

Droplet inhalation

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9
Q

Give some risk factors for active TB?

A

Immunosuppression
Intravenous drug use
Drug and alcohol misuse
Homelessness
Ethnic minority background - particularly sub-saharan africa and south asia

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10
Q

Name the bacteria found on microscopy indicating TB

A

Acid fast bacilli

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11
Q

Define COPD

A

Irreversible, progressive obstruction of the airways

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12
Q

Give some potential findings on a chest X-Ray of a patient with COPD?

A

Hyperinflation
Bullae
Flattened hemidiaphragms
Decreased peripheral vascular markings

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13
Q

Give some signs of hypercapnia?

A

Confusion
Asterixis
Bounding pulse
Reduced consciousness

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14
Q

Risk factors for Aspiration pneumonia

A

Stroke,
Bulbar palsy,
Myasthenia gravis,
Alcoholism
Post-ictal state
Achalasia
GORD

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15
Q

What is the duration of anticoagulation therapy for PROVOKED PE?

A

3 months

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16
Q

What is the duration of anticoagulation therapy for UNPROVOKED PE?

A

6 months

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17
Q

What is the first-line treatment for massive PE?

A

IV Alteplase

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18
Q

What would you find on ECG indicating PE?

A

Sinus Tachycardia
S1Q3T3 (deep S waves in lead I, pathological Q waves in lead III and inverted T waves in lead III)

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19
Q

How do you define Acute Respiratory Distress Syndrome?

A
  • Defined as non-cardiogenic pulmonary oedema and diffuse lung inflammation, typically secondary to an underlying illness.
  • The pathophysiology includes diffuse alveolar damage with hyaline membrane formation
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20
Q

What are some causes of ARDS?

A
  • Pneumonia
  • Sepsis
  • Aspiration
  • Pancreatitis
  • Transfusion reactions
  • Trauma and fractures
  • Fat embolism
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21
Q

What would you see on CXR for ARDS?

A

Reveals bilateral alveolar infiltrates, without other features of heart failure such as a cardiomegaly and Kerley B Lines

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22
Q

What is the management of ARDS?

A
  • Transfer to ITU for Cardiorespiratory support
  • Ventilatory support: A low tidal volume is associated with better outcomes
  • Haemodynamic support (to maintain MAP >60mmHg)
  • DVT prophylaxis
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23
Q

What is Asbestosis?

A

It is a diffuse interstitial lung fibrosis that develops in patients with pleural plaque disease who have been exposed to asbestos.

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24
Q

What are the signs and symptoms of Asbestosis?

A
  • Dyspnoea
  • Chronic cough
  • Crepitations on auscultation
  • Finger clubbing
  • Cyanosis
  • Reduced Chest expansion
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25
Q

What might a CXR show in someone with Asbestosis?

A
  • Linear interstitial fibrosis
  • Pleural plaques
  • Pleural thickening
  • Atelectasis
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26
Q

What should you do when a person with asbestosis dies?

A

Report to the coroner

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27
Q

What investigations could you do for aspiration pneumonia?

A
  • CXR: To visualise any infiltrates or consolidation
  • Sputum culture: To identify the causative organism
  • Blood tests: To assess the severity of the infection and the patients overall health status
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28
Q

What is the most common cause of Aspiration pneumonia?

A

Streptococcus pneumoniae

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29
Q

What type of lung disease is Asthma?

A

A chronic inflammatory disease which is a type of obstructive lung disease

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30
Q

What is the pathophysiology of asthma?

A

Occurs because of reversible airway obstruction.
- Involves a Type 1 hypersensitivity reaction.

31
Q

What are some risk factors for Asthma?

A
  • Family history
  • Personal history of atopy
  • Maternal smoking
  • Viral infections
  • Lower socioeconomic status
32
Q

On a peak flow diary what is diagnostic of asthma?

A

Variability of >20% is diagnostic

33
Q

What would you see on spirometry in asthma?

A

FEV1/FVC <0.7 (obstructive spirometry)

34
Q

What is Step 1 of management for Asthma?

A

Start Short acting beta 2 agonist

35
Q

What is Step 2 of management for Asthma?

A

Start ICS and then use SABA as reliever

36
Q

What is Step 3 of management for Asthma in adults?

A

SABA (as reliever) +ICS + Start Long acting Beta 2 agonist

37
Q

What is Step 3 of management for Asthma in Children?

A

In children aged five and over, an inhaled long-acting β₂ agonist or a leukotriene
receptor antagonist can be considered as initial add-on therapy.

Add on to SABA + ICS

38
Q

What is Step 4 of management for Asthma in Adults?

A

If asthma control remains suboptimal after the addition of an inhaled long-acting
β₂ agonist then:
* increase the dose of inhaled corticosteroids from low dose to medium dose
in adults or from very low dose to low dose in children (5-12 years), if not
already on these doses.
or
* consider adding a leukotriene receptor antagonist.

39
Q

What is required for a patient with acute exacerbation of asthma to be discharged?

A

Stable on Salbutamol inhaler for 24 hours

40
Q

What are some causes of Bilateral hilar lymphadenopathy on CXR?

A
  • Inflammatory: Sarcoidosis
  • Infective: TB and mycoplasma
  • Neoplastic: Bronchial carcinoma and lymphoma
  • Interstitial lung disease
41
Q

What is Bronchiectasis?

A

Permanent dilation of the bronchi and bronchioles following direct damage to the airway walls.

This leads to mucus plugging and further recurrent infections

42
Q

What are the causes of Bronchiectasis?

A

Use the mnenmonic I CRAM:

Immune OVER-response – allergic bronchopulmonary aspergillosis (ABPA)

Immune UNDER-response – HIV, inherited immunodeficiencies, bone marrow suppression

Congenital – cystic fibrosis, Kartagener syndrome, primary ciliary dyskinesia, Young syndrome, yellow nail syndrome

*almost all patients with cystic fibrosis will ultimately develop severe bronchiectasis
Childhood infection – tuberculosis, measles, pertussis, pneumonia

Respiratory disease – COPD, pulmonary fibrosis

pulmonary fibrosis causes a ‘traction bronchiectasis’
as the interstitium fibroses, it contracts, thereby pulling the bronchiolar walls apart
Aspiration pneumonia

Mechanical obstruction – foreign body, tumour, lymph node, external compression

43
Q

What are the symptoms of Bronchiectasis?

A
  • Productive cough - large amounts of purulent sputum
  • Dyspnoea
  • Haemoptysis
  • Pleuritic pain
44
Q

What signs would you expect to see on on CXR in a patient with Bronchiectasis?

A
  • Thickened bronchial walls and cystic appearance, otherwise known as tramline and ring shadows
45
Q

What is the diagnostic investigation for bronchiectasis?

A

High Resolution CT scan

46
Q

What happens to the PaO2 and PaCO2 in type 2 respiratory failure?

A

Low PaO2 and raise PaCO2

47
Q

What electrolyte abnormality is commonly seen in sarcoidosis?

A

Hypercalcaemia

48
Q

What happens to the PaO2 and PaCO2 in type 1 respiratory failure?

A

Low PaO2 and normal PaCO2

49
Q

What value defines pulmonary hypertension?

A

A mean pulmonary arterial pressure of more than 20mmHg

50
Q

What lung function test outcome indicates obstructive lung disease?

A

A FEV1:FVC ratio of less than 70%

51
Q

What are the top causes of transudative pleural effusions?

A
  • Congestive cardiac failure
  • Hypoalbuminaemia
  • Hypothyroidism
  • Meigs syndrome
52
Q

What is the usual first-line medication for treating sarcoidosis?

A

Oral steroids

53
Q

What scoring system is used to assess sleepiness associated with obstructive sleep apnoea?

A

Epworth Sleepiness Scale

54
Q

What is the name for minimally invasive “keyhole” surgery to treat lung pathology, such as cancer?

A

Video-assisted thoracoscopic surgery (VATS)

55
Q

What are the criteria for using non-invasive ventilation to treat an exacerbation of COPD?

A
  • Persistent respiratory acidosis (pH<7.35 and PaCO2>6) despite maximal medical treatment
  • Potential to recover
  • Acceptable to the patient
56
Q

What lung function test outcome is used to determine the severity of COPD?

A

FEV1

57
Q

What is the most common organism causing COPD exacerbations?

A

Haemophilus influenzae

58
Q

How does a tension pneumothorax occur?

A

A pleural flap acts as a one way valve allowing air to enter but not leave the pleural space

59
Q

What picture would you see on an ABG in heroin overdose?

A

They would have hypoventilation and therefore a respiratory acidosis

60
Q

What investigation can you do after a negative result with spirometry

A

FeNO

61
Q

What is the first line management for OSA?

A

CPAP

62
Q

What is the diagnostic test for obstructive sleep apnoea?

A

Polysomnography

63
Q

What is the presentation of Pneumocystis Jirovecii?

A

A patient who is immunocompromised with a dry cough and exercise induced desaturations.

64
Q

What is the investigation of choice for PE in patients with significant renal impairment?

A

V/Q scans as the contrast media used during CTPAs in toxic

65
Q

What is OSA caused by?

A

Collapse of the pharyngeal airway. Characterised by episodes of apnoea during sleep.

66
Q

What are some of the risk factors of OSA?

A

Middle age
Male
Obesity
Alcohol
Smoking

67
Q

What do you use to assess OSA?

A

Epworth sleepiness scale

68
Q

What is Pulmonary hypertension?

A

Refers to increased resistance and pressure in the pulmonary arteries. It causes strain on the right side of the heart as it tries to pump blood through the the lungs

Defined as a Mean pulmonary arterial pressure of more than 20mmHg

69
Q

What are the groups of pulmonary hypertension?

A

Group 1 – Idiopathic pulmonary hypertension or connective tissue disease (e.g., systemic lupus erythematous)
Group 2 – Left heart failure, usually due to myocardial infarction or systemic hypertension
Group 3 – Chronic lung disease (e.g., COPD or pulmonary fibrosis)
Group 4 – Pulmonary vascular disease (e.g., pulmonary embolism)
Group 5 – Miscellaneous causes such as sarcoidosis, glycogen storage disease and haematological disorders

70
Q

What would an ECG should in pulmonary hypertension?

A

P pulmonale (peaked P waves)
Right ventricular hypertrophy (tall R waves in V1 and V2 and deep S waves in V5 and V6)
Right axis deviation
Right bundle branch block

71
Q

What would an CXR should in pulmonary hypertension?

A
  • Dilated pulmonary arteries
  • Right ventricular hypertrophy
72
Q

What is the treatment of idiopathic pulmonary hypertension?

A

Calcium channel blockers
Intravenous prostaglandins (e.g., epoprostenol)
Endothelin receptor antagonists (e.g., macitentan)
Phosphodiesterase-5 inhibitors (e.g., sildenafil)

73
Q

When would Long term oxygen therapy be offered to a patient?

A

Offer LTOT to patients with a pO2 of < 7.3 kPa or to those with a pO2 of 7.3 - 8 kPa and one of the following:
secondary polycythaemia
peripheral oedema
pulmonary hypertension

74
Q
A

Finals Flash Cards 🩺 (32 decks)

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