Resp drugs Flashcards
Side effects of TB drugs
Rifampicin: orange / red secretions
Isoniazid: Peripheral Neuropathy
Pyrazinamide: NV, light sensitivity , gout/join pain
Ethambutol: visual issues
SABA and mechanism
B2 in the airway smooth muscle,
activates adenylyl cyclase (AC) and increased cyclic (cAMP),
resulting in bronchodilation.
side effects Salbutamol
Tremor
Hypotension
Tachycardia
ICS
and OCS examples and mechanisms
beclometasone and Prednisolone( oral)
(GRα), entering the nucleus, and regulating gene expression
reduce inflammation
side effects of ICS and OCS
Oropharyngeal candidiasis (thrush)
Dysphonia (hoarse and weak voice)
Growth restrictions
Glaucoma
Diabetes
Cushing’s syndrome
SAMA and LAMA drug names and mechanism
- SAMA Ipratropium (non-selective)
- LAMA Tiotropuim (selective)
- LAMA/SAMA block M3,
- Inhibition of Gq-coupled
- reduction of intracellular Ca++ release,
resulting in smooth muscle relaxation and bronchodilation.
Side effects SAMA and LAMA
SAMA=Ipra
LAMA= Tio
Dry mouth
Dizziness
Oropharyngeal candidiasis
taste disturbance
Give examples of Methylxanthines
Theophylline
Aminophylline
side effects of LAMA tiotropium
Tiotropium: taste disturbance
side effects of xanthines
NV
Abdo pain
Hypokalemia
- Theophylline
- Aminophylline
mechanism of Methylxanthines 3 stages
THEO and AMINO
inhibiting (PDE),
increase (cAMP) ,
decreased (PKA)
relaxes smooth muscle.
Give examples of CysLT Receptor Antagonists
Montelukast LTRA antagonist blocking the action of leukotrienes, which are inflammatory mediators involved in asthma and allergic rhinitis.
mechanism LTRA
Montelukast is a leukotriene receptor antagonist (LTRA) that specifically targets the CysLT1 receptor.
Issues with LTRA (AH)
Abdominal Pain
Headaches
CROMONES
Cromoglicate
Allergic asthma
Decreases sensitivity of expose C-fibres in endothelium
