Resp Cancers Flashcards
Paraneoplastic syndrome in small cell carcinomas
SIADH
Cushing’s syndrome
Lambert-Eaton syndrome
In Lung ca
compression of
recurrent laryngeal nerve
hoarseness
In Lung ca
compression of phrenic nerves results in
difficulty breathing,
In Lung ca
compression of superior vena cava results in
facial swelling or puffiness
Where do Pancoast tumors arise (non-small cell carcinomas)
superior sulcus, which is the space formed by the subclavian vessels
Sx Pancoast tumors
arm muscle weakness and paresthesia
Horner syndrome
Adenocarcinomas:
arise from
Associated genes
-form glandular structures or have the ability to generate mucin.
associated with mutations of the KRAS, EGFR and ALK genes.
Where do carcinoid tumors arise from
mature neuroendocrine cells
Where do squamous cell carcinomas come from
the cells are square shaped cells and produce keratin
squamous cell carcinoma location & association
squamous cell carcinoma tends to be centrally located. It has the highest association with smoking
Adenocarcinomas develop where & associated with .
adenocarcinomas
-peripherally, in a bronchiole or alveolar wall,
- associated with non-smokers.
What do carcinoid tumors secrete
& what does this leads to
carcinoid tumors
-serotonin,
=increased peristalsis and diarrhea, facial flushing, & wheezing due to bronchoconstriction.
‘cherry red ball’ often seen on bronchoscopy
Lung carcinoid
