Resistance

Question 1

What is E.coli resistant to?

Answer 1

Ciprofloxacin & certazidime

Question 2

What are the two types of acquire antibiotic resistance?

Answer 2

Spontaneous mutation and horizontal acquired resistance

Question 3

What are the mechanisms of antibacterial resistance?

Answer 3

Altered target site
Decreased uptake
Inactivation or modification
Bypass

Question 4

What mediates rifampicin resistance to S.aureus?

Answer 4

Alteration of RNA polymerase

Question 5

What happens in beta lactam resistance to PBPs?

Answer 5

Inter species recombination

Question 6

What species does mosaic PBPS occur?

Answer 6

Neisseria & streptococcus

Question 7

What makes S.Aureus resistant to linezolid?

Answer 7

Methylation of ribosomal RNA 
Also chloramphenicol
Lincosamides
Streptogramins
Pleuromutilins

Question 8

Why is vancomycin resistant to S.aureus?

Answer 8

Target overexpression

Question 9

What multiple drug efflux system does E.coli have?

Answer 9

AcrAB/TolC

Question 10

What enzymatic modifications do aminoglycosides cause?

Answer 10

Adenyltransferase
Acetyltransferases
Phosphotransferases

Question 11

What is S.Aureus resistant to?

Answer 11

Methicillin

Target bypass