General

Question 0

How are chemotherapeutic drugs found?

Answer 0

Serendipity
Empirical screening of natural products
Synthetic modification
Target driven approaches

Question 1

Where do drugs come from?

Answer 1

Micro-organisms
Plants
Man-made

Question 2

Through what mechanisms do chemotherapeutic drugs work?

Answer 2

Inhibition
Pro drugs
False substrates

Question 3

What is the therapeutic index?

Answer 3

Ratio of the dose that produces toxicity to the dose that produces a clinically desired of effective response

Question 4

What is better, a larger or smaller therapeutic index?

Answer 4

Larger. Means there is wider margin between doses that are effective and doses that are not toxic.

Question 5

What are the two types of administration? And what divides them?

Answer 5

Enteral: via the GI tract
Parenteral: avoids first pass effect

Question 6

What are the types of parenteral administration?

Answer 6

Intramuscular
IV
Subcutaneous 
Topical
Inhalation
Rectal
Transdermal
Intrathecal

Question 7

What is the bioavailability of a drug?

Answer 7

The fraction of metabolised drug that reaches the systemic circulation in an unchanged form

Question 8

What is the definition of distribution?

Answer 8

Process by which a drug reversibly leaves the blood stream and enters the extracellular fluid and or cells of tissues and organs

Question 9

What are the two forms of drug metabolism?

Answer 9

Conversion of lipophilic drugs into more polar molecules through reactions catalysed by cytochrome P450 system
Conjugation reactions