Antivrial Therapy

Question 0

What are the main targets of antiviral drugs?

Answer 0

Reverse transcriptase
Integrate
Protease

Question 1

What does HIV attack?

Answer 1

Virus infects CD4 positive cells (T lymphocytes, macrophages and dendritic cells)
Leads to progressive qualitative and quantitive decline in CD4 positive lymphocytes

Question 2

What are the three classes of drug licensed for HIV?

Answer 2

Nucleoside reverse transcriptase inhibitors
Non-nucleoside reverse transcriptase inhibitors
Protease inhibitors

Question 3

What type of therapy is commonly used for HIV?

Answer 3

HAART (highly active antiviral therapy)

Question 4

What is a selective inhibitor of reverse transcriptase?

Answer 4

AZT

Question 5

What does AZT bind to with greater affinity than?

Answer 5

Reverse transcriptase, greater than deoxythymidine triphosphate

Question 6

How does fusion occur?

Answer 6

The viral glycoproteins contain a fusion peptide

Question 7

What are the two glycoproteins in HIV?

Answer 7

Gp120 and gp41

Question 8

Which glycoprotein in HIV is the fusion peptide?

Answer 8

Gp41

Question 9

What does the entry inhibitor do?

Answer 9

Blocks conformational change involved with fusion of viral and cellular membranes by gp41 fusion domain