Fungal I Flashcards

1
Q

Are fungi eukaryotic or prokaryotic?

A

Eukaryotic

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2
Q

What is the cell wall made up of?

A

Carbohydrate

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3
Q

What are the three forms of Fungi?

A

Saprophytic (growing in rotting veg), parasitic, symbiotic

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4
Q

What are the three types of fungal infection?

A

Superficial, subcutaneous & systemic (affects deep seated tissues)

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5
Q

What are dermatophytes?

A

Specialised fungi, exploit keratin in hair, skin and nails

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6
Q

What are the three types of dermatophyte infection?

A

Trichophyton, Microsporon and epidermophyton

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7
Q

What fungal species is responsible for fungal and vaginal thrush?

A

Candida sp. (can cause systemic and superficial infections)

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8
Q

What are the different types of candida?

A

Albicans, Glabrata, parapsilosis, tropicalis and krusei

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9
Q

What fungal causes subcutaneous infections?

A

Sporotricosis - traumatic implantation, not endemic to UK. Associated with sphagum moss and disease tracks along lymph nodes. Can grow as yeast in tissue or as hyphae

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10
Q

How is systemic fungal infections diagnosed?

A

Isolation of fungus from blood or tissue

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11
Q

Where is systemic candidosis found?

A

blood, meninges, heart, bone and eye

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12
Q

What can systemic candidosis cause?

A

Blinds - gets into the back of the eye

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13
Q

What are the different types of aspergillus?

A
Allergic Bronchopulmonary Aspergillosis
Aspergilloma 
Aspergillum sinusitis
Chronic pulmonary aspergillosis
Invasive aspergillosis (immunocompromised)
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14
Q

What is invasive aspergillosis?

A

Pulmonary aspergillosis with active tissue and blood vessel invasion. May spread to brain, skin, kidney and other organs

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15
Q

What is mucormycosis?

A

Caused by a group of moulds

Rhino-cerebral or pulmonary disease in immunocompormised patients

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16
Q

What is cryptococcosis caused by?

A

Yeast

17
Q

What does cryptococcosis cause?

A

Pulmonary heart disease and meningitis

18
Q

What type of fungi causes histoplasmosis?

A

Dimorphic fungi - in the environment it is a mould and in the human a yeast

19
Q

What can histoplasmosis cause?

A

Pulmonary infection that can spread to other organs

20
Q

What are the main classes of antifungal agents?

A

Pyrimidine, polyenes, azole and echinocandins