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MS3 - Histopathology > Reproductive Pathology > Flashcards

Reproductive Pathology Flashcards

1
Q

Breast tissue anatomy

A

Parenchymal tissue - glandular

Connective tissue

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2
Q

Parenchymal tissue

A 
Branching duct system
Terminal duct lobular units
Subsegmental duct
Segmental duct
Collecting/lactiferous duct
Nipple
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3
Q

Secretory portion of breast tissue

A

Terminal duct lobular units

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4
Q

Cell layers of ductal lobular system

A

Inner epithelial cells

Outer myoepithelial cells

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5
Q

Myoepithelial cell markers

A

SMM
p63
ck5/6

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6
Q

Breast disease classification

A

Inflammatory
Proliferative
Neoplastic

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7
Q

Inflammatory breast disease

A

Actue / Chronic mastitis
Mammary duct ectasia - dilation
Fat necrosis

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8
Q

Proliferative breast disease

A

Fibrocystic change

Radial scar

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9
Q

Neoplastic breast disease

A

Benign:
Fibroadenoma
Papilloma

Malignant:
Carcinoma
Sarcoma
Paget's disease
Phylloides tumour
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10
Q

Diffuse breast lumps

A

Fibrosis

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11
Q

Discrete breast lumps

A

Neoplasm
Cyst
Abscess
Hamartoma

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12
Q

Mobile breast lumps

A

Benign neoplasm

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13
Q

Tethered breast lumps

A

Tethered carcinoma

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14
Q

Milk nipple discharge

A

Pregnancy

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15
Q

Blood nipple discharge

A

Duct papilloma

Carcinoma

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16
Q

Nipple retraction

A

Invasive carcinoma

17
Q

Nipple erythema

A

Paget’s disease

Eczma

18
Q

Fibrocytic changes in breast tissue

A 
Cycle
E2 secretion
Breast epithelium proliferation
Burst
Inflammation
Fibrocytic change
19
Q

Fibrocytic change in breast tissue age group

A

25 - 45 yrs

20
Q

Fibroadenoma

A

Benign - no Rx
20-35 yrs
Proliferating ducts and connective tissue

21
Q

Fibroadenoma size changes

A

Increases size in pregnancy

Decreases size with age

22
Q

Phylloides tumour

A

40-60 yrs
Epithelial and mesenchymal elements
Benign or Malignant

23
Q

Phylloides tumour Mx

A

Wide local excision

24
Q

RFs for breast carcinoma

A 
F
Age
Early menarche
Late menopause
1st pregnancy > 30 yrs
Obesity
FH
25
Q

Genes associated with breast carcinoma

A

BRCA1 (ovary + breast) - chromosome 17

BRCA2 - chromosome 13

26
Q

Breast carcinoma classification

A

Ductal carcinoma in situ
Lobular carcinoma in situ

Invasive ductal carcinoma
Invasive lobular carcinoma

27
Q

Ductal carcinoma in situ Mx

A

Excision

28
Q

Lobular carcinoma in situ Mx

A

Bilateral mastectomy

29
Q

Breast screening program

A

Women 50-64 (now 69) yrs
Invited for mammogram
Every 3 yrs

MS3 - Histopathology (9 decks)

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