Liver Pathology maybe.....the histopathology curriculum is very vague, just go in with an open mind Flashcards

1
Q

Types of biopsy

A
Core - deep organ lesions
Punch - superficial organ lesions
Incisional (wedge)
Excisional
Organectomy
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2
Q

Stages of histopathology

A

Biopsy
Fixation
Processing

Minimum 7 days

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3
Q

Cytology techniques

A

FNAC

Exfoliative cytology

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4
Q

Benign disorders or liver

A

Haemangioma
Liver cell adenoma
Bile duct malformation
Focal nodularhyperplasia

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5
Q

Malignant disorders of liver

A

Hepatocellular carcinoma (HCC)
Angiosarcoma
Cholangiocarcinoma

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6
Q

Causes of HCC

A

Cirrhosis
Hep B/C
Autoimmune hepatitis
Chronic biliary disease

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7
Q

Fibrolammelar HCC

A

Histology: blue fibrotic tissue

Younger pts

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8
Q

HCC on histology

A

Bile within duct

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9
Q

Causes of liver angiosarcoma

A

Arsenic
Thorotrast
Steroids
Vinyl chloride

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10
Q

Cholangiocarcinoma

A

Cancer of bile duct epithelial cells

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11
Q

Viral hepatitis

A

Hep A B C D E

You should have seen the ridiculous flashcard you had for all of these

Hssssssss

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12
Q

Hep A transmission

A

Faeco oral

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13
Q

Hep A Sx

A

Mild or lead to liver failure

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14
Q

Hep B transmission

A

Body fluid

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15
Q

Hep B Sx

A

Leads to cirrhosis and HCC

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16
Q

Hep C transmission

17
Q

Hep C Sx

A

Leads to cirrhosis and HCC

18
Q

Hep D transmission

A

Co infection with Hep B

19
Q

Hep D Sx

A

Leads to fulminant hepatitis (acute liver failure and encephalopathy)

20
Q

Hep E transmission

A

Food/water

21
Q

Hep E Sx

A

Acute / fulminant

22
Q

Pts in whom Hep E is more severe

A

Pregnant

Children

23
Q

Causes of Non Alcoholic Fatty Liver Disease

A

Alcohol
Obesity
Diabetes
Drugs

24
Q

Autoimmune hepatitis consequences

A

Cirrhosis

HCC

25
Ix for Autoimmune hepatitis
High ALT High IgG ANA positive
26
Mx of Autoimmune hepatitis
Steroids | Immunosuppression
27
Primary Sclerosing Cholangitis
Autoimmune | Large bile ducts affected
28
Ix for Primary Sclerosing Cholangitis
AMA negative | ?pANCA positive
29
Primary Biliary Cirrhosis
Autoimmune | Small bile ducts
30
Ix for primary biliary cirrhosis
AMA negative IgM positive High ALP
31
Wilson's disease
Abnormal storage of copper in liver, iris, etc
32
Sx of Wilson's disease
Liver failure
33
Genetics of Wilson's disease
Chromosome 13 | Autosomal recessive
34
Haemochromatosis
Increased iron absorption/storage in liver
35
Sx of Haemochromatosis
Cirrhosis | HCC
36
Genetics of Haemochromatosis
Chromosome 6, HFE gene | Autosomal recessive
37
Alpha 1 antitrypsin deficiency
Abnormal protein accumulation in liver
38
Sx of Alpha 1 antitrypsin deficiency
Fibrosis Cirrhosis HCC
39
Genetics of Alpha 1 antitrypsin deficiency
Chromosome 14