Liver Pathology maybe.....the histopathology curriculum is very vague, just go in with an open mind

Question 1

Types of biopsy

Answer 1

Core - deep organ lesions
Punch - superficial organ lesions
Incisional (wedge)
Excisional
Organectomy

Question 2

Stages of histopathology

Answer 2

Biopsy
Fixation
Processing

Minimum 7 days

Question 3

Cytology techniques

Answer 3

FNAC

Exfoliative cytology

Question 4

Benign disorders or liver

Answer 4

Haemangioma
Liver cell adenoma
Bile duct malformation
Focal nodularhyperplasia

Question 5

Malignant disorders of liver

Answer 5

Hepatocellular carcinoma (HCC)
Angiosarcoma
Cholangiocarcinoma

Question 6

Causes of HCC

Answer 6

Cirrhosis
Hep B/C
Autoimmune hepatitis
Chronic biliary disease

Question 7

Fibrolammelar HCC

Answer 7

Histology: blue fibrotic tissue

Younger pts

Question 8

HCC on histology

Answer 8

Bile within duct

Question 9

Causes of liver angiosarcoma

Answer 9

Arsenic
Thorotrast
Steroids
Vinyl chloride

Question 10

Cholangiocarcinoma

Answer 10

Cancer of bile duct epithelial cells

Question 11

Viral hepatitis

Answer 11

Hep A B C D E

You should have seen the ridiculous flashcard you had for all of these

Hssssssss

Question 12

Hep A transmission

Answer 12

Faeco oral

Question 13

Hep A Sx

Answer 13

Mild or lead to liver failure

Question 14

Hep B transmission

Answer 14

Body fluid

Question 15

Hep B Sx

Answer 15

Leads to cirrhosis and HCC

Question 16

Hep C transmission

Answer 16

Blood

Question 17

Hep C Sx

Answer 17

Leads to cirrhosis and HCC

Question 18

Hep D transmission

Answer 18

Co infection with Hep B

Question 19

Hep D Sx

Answer 19

Leads to fulminant hepatitis (acute liver failure and encephalopathy)

Question 20

Hep E transmission

Answer 20

Food/water

Question 21

Hep E Sx

Answer 21

Acute / fulminant

Question 22

Pts in whom Hep E is more severe

Answer 22

Pregnant

Children

Question 23

Causes of Non Alcoholic Fatty Liver Disease

Answer 23

Alcohol
Obesity
Diabetes
Drugs

Question 24

Autoimmune hepatitis consequences

Answer 24

Cirrhosis

HCC

Question 25

Ix for Autoimmune hepatitis

Answer 25

High ALT
High IgG
ANA positive

Question 26

Mx of Autoimmune hepatitis

Answer 26

Steroids

Immunosuppression

Question 27

Primary Sclerosing Cholangitis

Answer 27

Autoimmune

Large bile ducts affected

Question 28

Ix for Primary Sclerosing Cholangitis

Answer 28

AMA negative

?pANCA positive

Question 29

Primary Biliary Cirrhosis

Answer 29

Autoimmune

Small bile ducts

Question 30

Ix for primary biliary cirrhosis

Answer 30

AMA negative
IgM positive
High ALP

Question 31

Wilson’s disease

Answer 31

Abnormal storage of copper in liver, iris, etc

Question 32

Sx of Wilson’s disease

Answer 32

Liver failure

Question 33

Genetics of Wilson’s disease

Answer 33

Chromosome 13

Autosomal recessive

Question 34

Haemochromatosis

Answer 34

Increased iron absorption/storage in liver

Question 35

Sx of Haemochromatosis

Answer 35

Cirrhosis

HCC

Question 36

Genetics of Haemochromatosis

Answer 36

Chromosome 6, HFE gene

Autosomal recessive

Question 37

Alpha 1 antitrypsin deficiency

Answer 37

Abnormal protein accumulation in liver

Question 38

Sx of Alpha 1 antitrypsin deficiency

Answer 38

Fibrosis
Cirrhosis
HCC

Question 39

Genetics of Alpha 1 antitrypsin deficiency

Answer 39

Chromosome 14