Reproductive Drugs Flashcards
Estradiol
Hormone
replacement
therapy (HRT),
menopause,
prostate cancer,
In combination
contraceptives
Adverse:
Photosensitivity
MI,
thromboembolism
headache
N & V, bloating
breakthrough
bleeding
Herbals: - black
cohosh
Contraindicated in
history of breast
cancer or
estrogen-
dependent cancer
Norethindrone
acetate
Amenorrhea,
abnormal uterine
bleeding,
endometriosis
component of
hormonal
contraceptives
Adverse: venous
thromboembolism
diplopia
migraine
headache
breakthrough
bleeding, spotting,
amenorrhea
fluid
retention, edema,
weight gain
Drug / drug
interactions:
antibiotics,
phenytoin,
barbiturates, St
John’s wort
use another
method of
contraception
while on these
drugs
Clomiphene
reatment of
Infertility
Treatment of
ovarian failure in
patients with
normal liver
function and
endogenous
estrogens
Off label:
treatment of male
sterility
Adverse: Vasomotor
flushing
visual
changes
abdominal
discomfort,
distention and
bloating, N/V
ovarian
enlargement,
breast tenderness,
ovarian
Monitor for
ovarian
overstimulation,
possibility for
multiple births
need support and
encouragement to
deal with the self-
esteem issues
associated with
infertility
Oxytocin
Induction of labor,
Promotes uterine
contractions
postpartum,
stimulates milk let
down (lactation
deficiency),
stimulate
reinforce labor
(uterine inertia),
manage
incomplete
abortion, control
postpartum
bleeding/
hemorrhage
Adverse: arrhythmias,
HTN, fetal
bradycardia
nausea,
vomiting
uterine
rupture, pelvic
hematoma,
uterine hyper
tonicity
severe
water intoxication
anaphylactic
reaction
Discontinue with
any sign of uterine
hypertonicity
Testosterone
Replacement
therapy in cases of
hypo-gonadism
Androgenic
effects: Acne,
edema, hirsutism,
deepening of
voice, weight gain,
testicular atrophy
Adverse: headache,
dizziness, sleep
disorders
rash
electrolyte
imbalance
Available via:
injection, buccal,
topical gel, topical
spray, urethral
palate, and dermal
patch
Caution: liver
dysfunction or
cardiovascular
disease
Topical Black box
warning: Don’t get on children
Sildenafil
Erectile
Dysfunction
Pulmonary arterial
HTN
GU: priapism,
fibrosis, UTI
Systemic: flushing,
rash
Adverse: headache
dyspepsia,
Nausea, vomiting
Administration:
Onset of 27
minutes and
duration of 4
hours
Contraindicated:
bleeding
disorders, CAD,
peptic ulcer hypo
or hypertension
Avoid grapefruit juice and Nitrates
Anabolic Steroids
Treat anemias,
certain cancers,
and angio-edema
to promote weight
gain and tissue
repair in
debilitated
patients
Can be used for ↑
athletic
performance by ↑
muscle mass and
endurance.
Adverse: life-
threatening
hepatitis
Prepubertal
males: virilization
Post pubertal
males: testicular
dysfunction,
atrophy, priapism,
baldness, and
change in libido
Women:
hirsutism,
hoarseness,
clitoral
enlargement,
menstrual
irregularities
Contraindicated:
liver dysfunction,
coronary disease,
or prostate/breast
cancer
Class III controlled
substance
Drug to Drug with
anticoagulants &
lower need for anti-
diabetic agents
