Endocrine Drugs Flashcards
Leuprolide
Advanced
prostate
cancer;
endometriosis
central
precocious
puberty that
results from
hypothalamic
activity
Adverse:
Sweating, hot
stroke
MI, PE,
peripheral edema
GI bleed
hepatotoxicity,
Subcutaneous, IM
May have ↑ bone
pain initially
Monitor hepatic
and renal function
Very expensive
Somatropin
Long-term
treatment of
growth failure
in children
GH deficiency
in adults
AIDS wasting
Adverse: headache
edema
Hormone: insulin
resistance
joint pain
Pain at injection
site
Injection
Contraindicated if
closed epiphyses
May develop
antibodies to GH
Teaching (p584)
Storage &
reconstitution of
drug
Administration
techniques
Desmopressin
Diabetes
insipidus
Hemophilia A
Adverse: slight ↑ BP
phlebitis at
IV site; facial
flushing,
Water
intoxication with
high doses
(drowsiness, light-
headedness, headache, coma, seizures)
PO, intranasal, IV
Caution with renal
dysfunction,
vascular disease,
epilepsy, asthma,
hyponatremia
Nasal spray
Dexamethasone/
Prednisone/
Cortisone (mineral)
Short term
treatment of
inflammatory
disorders
Exacerbation
of MS.
Arthritis
Chemo
induced
Nausea /
vomiting
Replacement
therapy for
adrenal
insufficiency
(when
combined with
mineralcort-
icosteroid)
Adverse: depression,
euphoria,
headache
peptic ulcers,
N & V
HTN, HF,
↓ wound
healing, fragility
adrenal
suppression,
Cushingoid
appearance
(moon face,
buffalo hump)
↑ risk of infection
Hem:
thromboembolis
m
Increases fluid
volume; sodium
and water
retention
Metabolic:
weight gain
Musculoskeletal:
Osteoporosis,
spontaneous
fractures, muscle
weakness
May have effects
from all routes of
administration
Frail Skin
African Americans
may develop
toxicity to
methylprednisolon
e when used for
immunosuppressio
n after transplant
Drug-drug
interactions –
Several drugs
including
barbiturates,
phenytoin, or
rifampin
“moon face”
Administration:
Give 8-9 am to
mimic normal peak
diurnal
concentration
levels
Give with food to
avoid GI upset
Must taper doses
to discontinue
Avoid live virus
vaccines while
patient is
immunosuppressed
