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PHARM > REPRODUCTION > Flashcards

REPRODUCTION Flashcards

1
Q

GnRH agonists

A

-RELIN

LEUPROLIDE

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2
Q

tx for prolactinoma

A

cabergoline
bromocriptine

both are DA agonists

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3
Q

GnRH antagonists

A

-RELIX

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4
Q

aromatase inhibitors

A

letrozole
anastrozole
exemestane
formestane

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5
Q

5-alpha reductase inhibitors

A

finasteride

dutasteride

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6
Q

purpose of 5-alpha reductase inhibitors

A 
BPH
androgenic alopecia (finasteride)
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7
Q

purpose of aromatase inhibitors

A

ER+ breast cancer

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8
Q

SERMs

A

tamoxifen
raloxifene
CLOMIPHENE

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9
Q

SE of tamoxifen

A

increased risk for ENDOMETRIAL cancer

stroke, PE, cataract

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10
Q

tamoxifen used for

A

prevention of breast cancer
palliative tx for metastatic breast cancer
tx after lumpectomy

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11
Q

clomiphene used for

A

female infertility due to ovulatory disorder

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12
Q

ER antagonist

A

fulvestrant

tx for ER+breast cancer in postmenopausal women

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13
Q

clomiphene MOA

A

ER antagonist in hypothalamus and anterior pituitary
partial agonist in ovaries

disinhibits GnRH release leading to increase LH+FSH
promotes follicle growth

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14
Q

androgen receptor antagonists

A

flutamide

spironolactone

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15
Q

flutamide MOA

A

prevents binding of testosterone and DHT to tissue

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16
Q

flutamide clinical use

A

BPH

metastatic prostate cancer (preferred over leuprolide)

17
Q

spironolactone clinical use

A 
acne vulgaris
edema
hirsutism 
hypertension
hypokalemia
primary aldosteronism
18
Q

SE of spironolactone

A

hyperkalemic metabolic acidosis
gynecomastia
impotence
SLE**

19
Q

progesterone receptor antagonists

A

mifepristone

asoprsnil**

20
Q

**mifepristone can also treat?

A

at high doses, blocks glucocorticoid receptor

can treat ECTOPIC ACTH syndrome**

21
Q

estrogens

A

ethinyl estradiol

mestranol

22
Q

progestins

A

norgestrel
levonorgestrel (PLAN B)
norethindrone
norethindrone acetate

23
Q

progestin only contraceptives

A

norgestrel
norethindrone
medroxyprogesterone acetate
etonogestrel

24
Q

androgens used for hormone replacement

A

testosterone enanthate*

testosterone cypionate

PHARM (7 decks)

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