REPRODUCTION Flashcards
GnRH agonists
-RELIN
LEUPROLIDE
tx for prolactinoma
cabergoline
bromocriptine
both are DA agonists
GnRH antagonists
-RELIX
aromatase inhibitors
letrozole
anastrozole
exemestane
formestane
5-alpha reductase inhibitors
finasteride
dutasteride
purpose of 5-alpha reductase inhibitors
BPH androgenic alopecia (finasteride)
purpose of aromatase inhibitors
ER+ breast cancer
SERMs
tamoxifen
raloxifene
CLOMIPHENE
SE of tamoxifen
increased risk for ENDOMETRIAL cancer
stroke, PE, cataract
tamoxifen used for
prevention of breast cancer
palliative tx for metastatic breast cancer
tx after lumpectomy
clomiphene used for
female infertility due to ovulatory disorder
ER antagonist
fulvestrant
tx for ER+breast cancer in postmenopausal women
clomiphene MOA
ER antagonist in hypothalamus and anterior pituitary
partial agonist in ovaries
disinhibits GnRH release leading to increase LH+FSH
promotes follicle growth
androgen receptor antagonists
flutamide
spironolactone
flutamide MOA
prevents binding of testosterone and DHT to tissue
flutamide clinical use
BPH
metastatic prostate cancer (preferred over leuprolide)
spironolactone clinical use
acne vulgaris edema hirsutism hypertension hypokalemia primary aldosteronism
SE of spironolactone
hyperkalemic metabolic acidosis
gynecomastia
impotence
SLE**
progesterone receptor antagonists
mifepristone
asoprsnil**
**mifepristone can also treat?
at high doses, blocks glucocorticoid receptor
can treat ECTOPIC ACTH syndrome**
estrogens
ethinyl estradiol
mestranol
progestins
norgestrel
levonorgestrel (PLAN B)
norethindrone
norethindrone acetate
progestin only contraceptives
norgestrel
norethindrone
medroxyprogesterone acetate
etonogestrel
androgens used for hormone replacement
testosterone enanthate*
testosterone cypionate
