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PHARM > ASTHMA > Flashcards

ASTHMA Flashcards

1
Q

anticholinergics

A

tiotroprium | ipratropium

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2
Q

anticholinergics MOA

A

antagonist M3 receptor in lungs leading to decreased bronchoconstriction and mucus secretion

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3
Q

main clinical use of anticholinergics

A

COPD

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4
Q

epinephrine acts on which receptors

A

alpha1, beta1 + beta2

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5
Q

isoproterenol acts on which receptors

A

beta 1 = beta 2

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6
Q

long acting beta agonists

A

salmeterol
formoterol
arformoterol

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7
Q

SE of LABA

A

sudden death if monotherapy

therefore give with corticosteroids

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8
Q

methylxanthines

A

theophylline

aminophylline

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9
Q

methylxanthines MOA

A

inhibit phosphodiesterase 3+4 - leading to increased cAMP - this also has an anti inflammatory effect

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10
Q

what daily beverage is used to prevent asthma

A

coffee - caffeine and theophylline are related

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11
Q

what can be given to prevent calcium from entering smooth muscle cells

A

magnesium sulfate

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12
Q

clinical uses of MAGNESIUM SULFATE

A 
uterine relaxation 
delay preterm labor
cerebral edema
barium poisoning
eclampsia
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13
Q

acute exacerbation asthma in ER. give which drug

A

magnesium sulfate

beta 2 agonist

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14
Q

which drug should be given for HYPOCALCEMIA

A

magnesium chloride

vit D

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15
Q

inhaled corticosteroids MOA

A

inhibit cox-2
increased lipocortins
anti inflammatory

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16
Q

name some inhaled corticosteroids

A

fluticasone
beclomethasone
budesonide
ciclesonide

17
Q
  • the most important drug class to treat asthma *
A

inhaled corticosteroids

18
Q
  • what to do if inhaled corticosteroids are ineffective *
A

give systemic corticosteroids

PREDNISONE

19
Q

“mast cell stabilizing agent”

A

cromolyns

20
Q

name the CROMOLYNs

A

cromolyn

nedocromil

21
Q

cromolyn MOA

A

inhibits chloride ion transports
leading to decreased calcium
and NO MAST CELL DEGRANULATION

22
Q

cromolyn main purpose

A

PROPHYLAXIS

exercise induced asthma

23
Q

major purpose of LEUKOTRIENE PATHWAY INHIBITORS

A

aspirin exacerbated respiratory distress

PGE2 usually down regulates 5-lipoxygenase pathway -
aspirin decreases PGE2 which increases leukotriene’s

24
Q

*monoclonal antibody against IgE receptor

A

omalizumab

25
Q

omalizumab clinical use

A

allergic asthma

26
Q

3 delivery systems for inhaled drugs

A
  1. nebulizer
  2. dry powder inhalers
  3. metered dose inhalers

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