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PHARM > 5-HT / CNS adrenergic > Flashcards

5-HT / CNS adrenergic Flashcards

1
Q

MDD

A

major depressive disorder
depressive episodes with NO MANIA
2 week period + interfering with ADL

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2
Q

types of MDD

A

typical ( melancholic )
atypical
psychotic

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3
Q

BPAD

A

bipolar affective disorder

MANIC episode w or w/o depression

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4
Q

inhibitors of 5-HT storage

A

amphetamine
methamphetamine
methylphenidate

modafinil
dextroamphetamine
lisdexamfetamine

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5
Q

ADHD

A

dextroamphetamine

lisdexamfetamine

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6
Q

modafinil

A

atypical depression
narcolepsy
obstructive sleep apnea

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7
Q

irreversible MAOIs

A

iproniazid
phenelzine
isocarboxazid

no longer 1st line therapy b/c of SE

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8
Q

SE of MAOI

A

*tyramine toxicity - hypertensive crisis

precipitate manic or hypomanic episodes in bipolar patients

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9
Q

MAO-A inhibitors

A

brofaromine
befloxatone
moclobemide

reversible
less tyramine toxicity

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10
Q

MAO-B inhibitor

A

selegiline
-also MAO-A at higher doses

transdermal patch
better freedom w diet

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11
Q

MDMA

A

methylenedioxymethamphetamine

SSRI + 5HT agonist

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12
Q

tyramine located in

A

red wine, processed meats, aged hard cheeses

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13
Q

MAOIs metabolized by

A

cytochrome P450 enzymes

lots of drug interactions

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14
Q

reserpine

A

blocks uptake of DA,5HT,NE by VMAT into vesicles

can induce depression

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15
Q

TCA

A
  • TRIPTYLINE ( amitriptyline )

- IMPRAMINE ( imipramine )

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16
Q

TCA mechanism of actions

A

blocks NET and SERT

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17
Q

TCA SE

A

*conduction delays
*orthostatic HTN in elderly
MI
jaundice, seizure

18
Q

SSRI

A

*fluoxetine
*paroxetine
*sertraline
fluvoxamine
citalopram

19
Q

SSRI SE

A

SEROTININ syndrome when given with MAOI
- muscle rigidity, hyperthermia, myoclonus, mental state/vital sign changes

sexual dysfunction
GI
-diarrhea ( SERTALINE causes you to Shit your pants )
-constipation ( PAROXETINE )

20
Q

SSRI uses

A 
typical depression
anxiety
OCD
PTSD
pain syndromes
21
Q

SNRIs

A

venlafaxine
duloxetine
desvenlafaxine
milnacipran

22
Q

neuropathic pain

A

duloxetine

gabapentine

23
Q

MDD

A

desvenlafaxine

24
Q

milnacipran

A

fibromyalgia

25
Q

NRIs

A

atomoxetine

26
Q

atomoxetine

A

ADHD

once daily dosing

27
Q

bupropion mechanism

A

weakly inhibits uptake of DA,5HT,NE

28
Q

bupropion uses

A

smoking cessation
atypical depression

fewest sexual SEs
less mania

29
Q

mirtazapine mechanism

A

blocks 5HT2 and alpha2 receptors

decreases 5HT and increases NE transmission

30
Q

mirtazapine use

A

depression

*stimulate appetite and weight loss in elderly

31
Q

TCAs uses

A

depression
nocturnal enuresis ( imipramine )
pain syndromes - migraine, chronic fatigue

32
Q

5-HT agonists

A

buspirone - 5HT1

-TRIPTANs ( suma- near- riza- ) - 5HT1B/1D

33
Q

buspirone

A

anxiety

34
Q

triptans

A

migraines

35
Q

5-HT receptor antagonist

A 
ketanserin
ondansetron
tegaserod
prucalopride
alosetron
36
Q

ketanserin

A

5HT2A/2C

glaucoma
HTN

37
Q

ondansetron

A

5HT3 antagonist

nausea

38
Q

tegaserod

prucalopride

A

5-HT4 ( Gs )

use - IBS with constipation

39
Q

alosetron

A

5-HT3 ( ligand gated )
use - IBS with diarrhea

alosetron “resets” the 5HT tone to decrease intestinal motility

40
Q

lithium MOA

A

enters via Na+ channels

blocks PIP2 pathway which inhibits adrenergic, muscarinic, and serotonergic

41
Q

lithium reacts with which other common drug

A

NSAIDs + hyponatremia

causes increased lithium reabsorption

42
Q

lithium SE

A 
nephrogenic DI
lithium toxicity ( ataxia, tremor, sedation, vomiting, hyperkalemia, increased ICP )

PHARM (7 decks)

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