HEMATOPOIESIS + IMMUNOMODULATION Flashcards
GM-CSF
sargramostim
G-CSF
filgrastim
G-CSF raises
neutrophils
GM-CSF raises
neutrophils + eosinophils
what are filgrastim and sargramostim used for
neutropenia
peripheral blood stem cell harvest
idiopathic thrombocytopenic purpura unresponsive to corticosteroids, immunoglobins, splenectomy
eltrombopag
romiplostim
endogenous receptor for thrombopoietin
Mpl
stimulate EPO
epoetin alfa
darbepoetin- longer half life
target hemoglobin level for patients with anemia and chronic kidney disease
10-12 g/dl
myelodysplastic syndrome
decitabine
hydroxyurea used for
sickle cell anemia CML head and neck cancer malignant melanoma ovarian carcinoma
hydroxyurea treats cancer thru which mechanism
inhibit ribonucleotide reductase
decitabine MOA
reverse methylation of gamma globin chain, increasing HbF expression
rhIL-11
oprelvekin
oprevelkin
prevention of severe chemotherapy induced thrombocytopenia
colon cancer combo
levamisole + 5FU
used TRETINOIN for
**acute promyelocytic leukemia
acne vulgaris
wrinkles of face
big side effect of TRETINOIN
ATRA syndrome
fever ARDS with pulmonary infiltrates, edema, weight loss, multisystem organ failure
oral drug for ITP
eltrombopag
subQ drug for ITP
romiplostim
how do the drugs for ITP work
they both bind the TPO receptor- agonist
