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PHARM > HEMATOPOIESIS + IMMUNOMODULATION > Flashcards

HEMATOPOIESIS + IMMUNOMODULATION Flashcards

1
Q

GM-CSF

A

sargramostim

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2
Q

G-CSF

A

filgrastim

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3
Q

G-CSF raises

A

neutrophils

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4
Q

GM-CSF raises

A

neutrophils + eosinophils

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5
Q

what are filgrastim and sargramostim used for

A

neutropenia

peripheral blood stem cell harvest

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6
Q

idiopathic thrombocytopenic purpura unresponsive to corticosteroids, immunoglobins, splenectomy

A

eltrombopag

romiplostim

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7
Q

endogenous receptor for thrombopoietin

A

Mpl

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8
Q

stimulate EPO

A

epoetin alfa

darbepoetin- longer half life

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9
Q

target hemoglobin level for patients with anemia and chronic kidney disease

A

10-12 g/dl

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10
Q

myelodysplastic syndrome

A

decitabine

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11
Q

hydroxyurea used for

A 
sickle cell anemia
CML
head and neck cancer
malignant melanoma 
ovarian carcinoma
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12
Q

hydroxyurea treats cancer thru which mechanism

A

inhibit ribonucleotide reductase

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13
Q

decitabine MOA

A

reverse methylation of gamma globin chain, increasing HbF expression

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14
Q

rhIL-11

A

oprelvekin

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15
Q

oprevelkin

A

prevention of severe chemotherapy induced thrombocytopenia

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16
Q

colon cancer combo

A

levamisole + 5FU

17
Q

used TRETINOIN for

A

**acute promyelocytic leukemia
acne vulgaris
wrinkles of face

18
Q

big side effect of TRETINOIN

A

ATRA syndrome

fever ARDS with pulmonary infiltrates, edema, weight loss, multisystem organ failure

19
Q

oral drug for ITP

A

eltrombopag

20
Q

subQ drug for ITP

A

romiplostim

21
Q

how do the drugs for ITP work

A

they both bind the TPO receptor- agonist

PHARM (7 decks)

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