GABA + GLUTAMATE Flashcards
inhibit GAT
tiagabine
“ti a gat”
inhibits GABA transaminase
vigabatrin
purpose of inhibitors of GABA metabolism
focal and tonic clonic seizures
adjunct therapy
benzo/barbiturates do what to P450 3A4
induce
MOA of benzodiazepines
increase FREQUENCY of CL- opening
benzodiazepine antagonist
flumazenil
MOA of barbiturates
increase duration of CL- opening
direct agonist at high concentration
*antagonize AMPA receptor
name the barbiturates
methohexital pentobarbital thiopental amobarbital secobarbital phenobarbital
which barbiturate undergoes both renal and hepatic clearance
phenobarbital
induction of anesthesia in hemodynamic unstable patients
etomidate
most commonly used anesthetic
propofol
GABA- B agonist
baclofen
use baclofen for
spasticity
riluzole
antagonize NMBA and voltage gated Na channels
for ALS
memnatine
only antagonize NMDA receptor
for Alzheimers
amantadine
only antagonize NMDA receptor
for Parkinsons and Influenza A prophylaxis
lamotrigine
only blocks voltage gated Na channels
for focal and tonic clonic seizures
atypical absence seizures
bipolar I disorder
felbamate
blocks both NMDA and Na channels
for epilepsy and tonic-clonic seizures
aplastic anemia caused by
felbamate
lamotrigine can cause what skin reaction
stevens Johnson syndrome
TOC for absence seizures
valproic acid
ethosuximide
