GABA + GLUTAMATE

Question 1

inhibit GAT

Answer 1

tiagabine

“ti a gat”

Question 2

inhibits GABA transaminase

Answer 2

vigabatrin

Question 3

purpose of inhibitors of GABA metabolism

Answer 3

focal and tonic clonic seizures

adjunct therapy

Question 4

benzo/barbiturates do what to P450 3A4

Answer 4

induce

Question 5

MOA of benzodiazepines

Answer 5

increase FREQUENCY of CL- opening

Question 6

benzodiazepine antagonist

Answer 6

flumazenil

Question 7

MOA of barbiturates

Answer 7

increase duration of CL- opening
direct agonist at high concentration
*antagonize AMPA receptor

Question 8

name the barbiturates

Answer 8

methohexital
pentobarbital
thiopental
amobarbital
secobarbital
phenobarbital

Question 9

which barbiturate undergoes both renal and hepatic clearance

Answer 9

phenobarbital

Question 10

induction of anesthesia in hemodynamic unstable patients

Answer 10

etomidate

Question 11

most commonly used anesthetic

Answer 11

propofol

Question 12

GABA- B agonist

Answer 12

baclofen

Question 13

use baclofen for

Answer 13

spasticity

Question 14

riluzole

Answer 14

antagonize NMBA and voltage gated Na channels

for ALS

Question 15

memnatine

Answer 15

only antagonize NMDA receptor

for Alzheimers

Question 16

amantadine

Answer 16

only antagonize NMDA receptor

for Parkinsons and Influenza A prophylaxis

Question 17

lamotrigine

Answer 17

only blocks voltage gated Na channels
for focal and tonic clonic seizures
atypical absence seizures
bipolar I disorder

Question 18

felbamate

Answer 18

blocks both NMDA and Na channels

for epilepsy and tonic-clonic seizures

Question 19

aplastic anemia caused by

Answer 19

felbamate

Question 20

lamotrigine can cause what skin reaction

Answer 20

stevens Johnson syndrome

Question 21

TOC for absence seizures

Answer 21

valproic acid

ethosuximide