Repro

Question 1

Preeclampsia

Answer 1

HTN

Proteinuria or end organ dysfunction after 20th week

Question 2

eclampsia

Answer 2

pre-eclampsia + maternal seizures

Question 3

HELLP syndrome

Answer 3

Hemolysis
Elevated Liver enzymes
Low Platelets

manifestation of severe pre-eclampsia
immediate delivery

Question 4

Cervical cancer

Answer 4

HPV 16 and 18 release
E6 → p53
E7 → Rb

koilocytes

Question 5

Polycystic Ovarian syndrome

Answer 5

amenorrhea
hirsutism
acne
↓ fertility
Associated with obesity, acanthosis nigricans
↑ risk of endometrial cancer

Question 6

Leuprolide

Answer 6

GnRH analog
Initial ↑ FSH and LH, but
↓ FSH and LH if used continuously

Question 7

clomiphene

Answer 7

Hypothalamic estrogen receptor blocker
prevents negative feedback
↑ FSH/LH → stimulates ovulation

Question 8

Tamoxifen

Answer 8

SERM
antagonist effect at breast → ↓ risk of breast cancer recurrence
agonist at uterus → ↑risk of endometrial cancer

Question 9

Raloxifene

Answer 9

SERM
agonist at bone → osteoporosis
antagonist at uterus → no risk of endometrial cancer

Question 10

Finasteride

Answer 10

5α-reductase inhibitor
↓ testosterone conversion to DHT
used for BPH

AA:
gynecomastia
sexual dysfunction

Question 11

Flutamide

Answer 11

Nonsteroidal competitive inhibitor at androgen receptors

used for prostate cancer

Question 12

Tamsulosin

Answer 12

α1 antagonist
↓ smooth muscle contraction
used for BPH urinary symptoms

Question 13

Sildenafil, tadalafil

Answer 13

PDE-5 inhibitors

↑ cGMP → prolong smooth muscle relaxation