MSK and Skin

Question 1

Polymyositis

Answer 1

proximal muscle weakness
endomysial inflammation
Anti-Jo-1
Anti-SRP
Anti-Mi-2

Question 2

Dermatomyositis

Answer 2

Proximal muscle weakness
perimysial inflammation (Peri is fixated on her skin)
Anti-Jo-1
Anti-SRP
Anti-Mi-2
Facial erythema
shawl and face rash
Gottron papules

Question 3

SS-A, SS-B
Anti-Ro
Anti-La

Answer 3

Sjogren syndrome

Question 4

Anti-CCP

Answer 4

RA

Question 5

needle shaped crystals

negative perfringence

Answer 5

gout

Question 6

rhomboid shaped crystal

weakly positive perfingence

Answer 6

pseudogout

calcium pyrophosphate crystals

Question 7

Legge-Calve-Perthes disease

Answer 7

avascular necrosis of femoral head

Question 8

Klumpke palsy

Answer 8

lower trunk
grabbing tree branch
claw hand

Question 9

Erb’s palsy

Answer 9

Upper trunk
neck traction/trauma
waiter's tip
deltoid
supra and infra spinatus mm.

Question 10

Anti-dsDNA

Answer 10

SLE

Question 11

Anti-sm

Answer 11

SLE
anti-smith antibodies
antibodies against snRNP which help spliceosomes splice introns

Question 12

McCune-Albright Syndrome

Answer 12

cafe au lait spots
fibrous dysplasia of bone
endocrine abnormalities
early puberty

Question 13

Diffuse scleroderma

Answer 13

Autoimmunity
noninflammatory vasculopathy
collagen deposition w/ fibrosis
widespread skin involvement
visceral organ invovlement

anti-Scl-70 (anti-DNA topoisomerase-I)
anti-RNA polymerase III

Question 14

Limited scleroderma

Answer 14

Autoimmunity
noninflammatory vasculopathy
collagen deposition w/ fibrosis
confined to fingers and face

CREST syndrome
Calcinonsis cutis
anti-Centromere
Raynauds
Esophageal dysmotility
Sclerodactyly
Telangiectasia

Question 15

anti-Centromere

Answer 15

CREST syn aka limited scleroderma

Question 16

anti-Scl-70

Answer 16

anti-DNA topoisomerase-I

Diffuse scleroderma

Question 17

anti-RNA polymerase III

Answer 17

Diffuse scleroderma

Question 18

basal cell carcinoma

Answer 18

waxy, pink, pearly nodules
rolled edges/umbilicated
central crust or ulceration

Question 19

Squamous cell carcinoma

Answer 19

Ulcerative, red lesion,
Crusty
keratinization
lower lip

Actinic keratosis precursor

Question 20

Melanoma

Answer 20

ABCDE
BRAF mutation
S-100
melanocytes have NCC origin

Question 21

Xeroderma pigmentosa

Answer 21

light sensitive skin, high risk of skin cancer

defective DNA excision repair of pyrimidines

Question 22

Collagen types

Answer 22

Big Church, Vast Basement, eh?
I → Bone
II → Cartilage
III → Vascular
IV → Basement membrane
V → Ehlers-Danlos (dermal-epidermal junction)

Question 23

UV light results in

Answer 23

pyrimidine dimerization
fixed by endonuclease nicking out defective DNA portion
filled in by DNA polyermase

Question 24

Pemphigus vulgaris

Answer 24

Desmosome autoantibodies
flaccid blisters, easily burstable
Nikolsky sign + 
oral and body lesions
potentially fatal
intra-epidermal

Question 25

Bullous pemphigoid

Answer 25

Hemidesmosome autoantibodies
tense blisters
Nikolsky sign -
dermal-epidermal junction

Question 26

angiosarcoma

Answer 26

Blood vessel malignancy

associated with post-masectomy lymphedema

Question 27

glomus tumor

Answer 27

red-blue tumor under nail bed

arises from thermoregulatory cells

Question 28

dermatitis herpetiformis

Answer 28

associated with celiac disease

rash (itchy papules, vesicles, and blisters) on elbows and knees