MSK and Skin Flashcards
Polymyositis
proximal muscle weakness endomysial inflammation Anti-Jo-1 Anti-SRP Anti-Mi-2
Dermatomyositis
Proximal muscle weakness perimysial inflammation (Peri is fixated on her skin) Anti-Jo-1 Anti-SRP Anti-Mi-2 Facial erythema shawl and face rash Gottron papules
SS-A, SS-B
Anti-Ro
Anti-La
Sjogren syndrome
Anti-CCP
RA
needle shaped crystals
negative perfringence
gout
rhomboid shaped crystal
weakly positive perfingence
pseudogout
calcium pyrophosphate crystals
Legge-Calve-Perthes disease
avascular necrosis of femoral head
Klumpke palsy
lower trunk
grabbing tree branch
claw hand
Erb’s palsy
Upper trunk neck traction/trauma waiter's tip deltoid supra and infra spinatus mm.
Anti-dsDNA
SLE
Anti-sm
SLE
anti-smith antibodies
antibodies against snRNP which help spliceosomes splice introns
McCune-Albright Syndrome
cafe au lait spots
fibrous dysplasia of bone
endocrine abnormalities
early puberty
Diffuse scleroderma
Autoimmunity noninflammatory vasculopathy collagen deposition w/ fibrosis widespread skin involvement visceral organ invovlement
anti-Scl-70 (anti-DNA topoisomerase-I)
anti-RNA polymerase III
Limited scleroderma
Autoimmunity
noninflammatory vasculopathy
collagen deposition w/ fibrosis
confined to fingers and face
CREST syndrome Calcinonsis cutis anti-Centromere Raynauds Esophageal dysmotility Sclerodactyly Telangiectasia
anti-Centromere
CREST syn aka limited scleroderma
anti-Scl-70
anti-DNA topoisomerase-I
Diffuse scleroderma
anti-RNA polymerase III
Diffuse scleroderma
basal cell carcinoma
waxy, pink, pearly nodules
rolled edges/umbilicated
central crust or ulceration
Squamous cell carcinoma
Ulcerative, red lesion,
Crusty
keratinization
lower lip
Actinic keratosis precursor
Melanoma
ABCDE
BRAF mutation
S-100
melanocytes have NCC origin
Xeroderma pigmentosa
light sensitive skin, high risk of skin cancer
defective DNA excision repair of pyrimidines
Collagen types
Big Church, Vast Basement, eh? I → Bone II → Cartilage III → Vascular IV → Basement membrane V → Ehlers-Danlos (dermal-epidermal junction)
UV light results in
pyrimidine dimerization
fixed by endonuclease nicking out defective DNA portion
filled in by DNA polyermase
Pemphigus vulgaris
Desmosome autoantibodies flaccid blisters, easily burstable Nikolsky sign + oral and body lesions potentially fatal intra-epidermal
