Renin-Angiotensin-Aldosterone System (RAAS) Flashcards
RAAS is controlled in the ___ using the ___
controlled in the kidney using the juxtaglomerular apparatus/complex
What does the juxtaglomerular complex consist of?
JG cells and macula densa
Where are JG cells?
Afferent and efferent arterioles
What is the function of JG cells?
Make and secrete renin (enzyme)
Where is the macula densa?
Distal convoluted tubule between afferent and efferent arterioles
What is the function of macula densa?
Stimulate JG cells to release renin, also releases NO
What is the macula densa sensitive to?
- low sodium chloride
- low blood pressure
- beta adrenergic stimulation from epinephrine
As macula densa releases nitric oxide, what is the effect?
Dilation of afferent arteriole
Renin enzymatically converts ___ (from liver) to ___
angiotensinogen (from liver) to angiotensin I
Where is ACE found?
Lungs
ACE, in lungs, converts ___ to ___
Angiotensin I to angiotensin II
What is the effect of angiotensin II on the adrenal glands?
Causes release of aldosterone from zona glomerulosa
What is the effect of angiotensin II on arterioles?
Constricts all arterioles, especially efferent arteriole
As the zona glomerulosa in the adrenal cortex releases aldosterone, what happens in the blood?
Sodium in blood serum increases
An increase in sodium blood serum levels will trigger what organ to release what chemical?
Posterior pituitary releases ADH