Renal tubular disease Flashcards by K D

Q

Renal tubular acidosis (RTA) def

A

metabolic acidosis caused by impaired acid secretion by kidneys

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Type 1 RTA

A

Inability to excrete H ions in the distal tubule

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Type 2 RTA

A

Defective HCO3 reabsorption in the proximal tubule

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Type 3

A

type 1+2

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Type 4 RTA

A

Low renin

Low aldosterone

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Causes of type 1 RTA

A

SLE

Sjogrens

Amphotericin (antifungal)

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Type 1 RTA sx

A

Rickets/osteomalacia (buffering of H with Ca)

UTIs

Calcium phosphate stones

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Ix for type RTA

A

urine pH <5.5 despite metabolic acidosis

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Rx of type 1 RTA

A

Calcium bicarb or citrate

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Dx of type 2 RTA

A

IV sodium bicarb

high fraction of excreted HCO3 (>15%)

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Rx of type 2 RTA

A

high dose bicarb

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Type 4 RTA causes

A

Addisons

Diabetic nephropathy

Interstitial nephritis

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Type 4 RTA rx

A

Rx cause

Rx hyperkalaemia

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Fanconi syndrome pathophysiology

A

proximal tubular defect

Loss of amino acids, glucose, PO4, HCO3 in urine

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Effect of Fanconi syndrome

A

dehydration

metabolic acidosis

osteomalacia/rickets

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Congenital causes of Fanconi

A

Wilson’s

Tyrosinaemia

Lowe syndrome

Q

Acquired causes of fanconi

A

heavy metal poisoning

gentamaicin

myeloma

amyloid

Sjograns

Q

Fanconi rx

A

replace missing stuff

remove cause

Q

Heridetary hypokalaemic tubulopathies

A

Bartter syndrome

Gitelman syndrome

Q

Bartter

A

low K

metabolic alkalosis

high urine Ca

Inherited version of LOOP DIURETICS effect

Q

Gitelman

A

Low K

Metabolic alkalosis

low urine Ca

Inherited version of THIAZIDEs effect