RENAL SYSTEM Flashcards
The kidneys are situated against the dorsal body wall
in a _____
retroperitoneal position (behind the parietal peritoneum)
The kidneys are situated at the level of the ___
T12 to L3
vertebrae
The right kidney is slightly ___
lower than the left
provides each kidney with arterial blood
supply
Renal artery
Each nephron consists of two main structures
- Renal corpuscle
- Renal tubule
Renal corpuscle consists
Glomerulus
Glomerular (Bowman’s) caps
Renal artery divides into
segmental arteries →
interlobar arteries → arcuate arteries → cortical
radiate arterie
SIAC
Foot processes cling to the glomerulus
a knot of capillaries made of podocytes
Glomerulus
Structural and functional units of kidneys
NEPHRONS
From the glomerular (Bowman’s) capsule, the
subdivisions of the renal tubule are:
- Proximal convoluted tubule (PCT)
- Nephron loop (loop of Henle)
- Distal convoluted tubule (DCT
make up the inner (visceral) layer of the glomerular capsule
Podocytes
Located entirely in the cortex
Include most nephron
Cortical nephrons
cup-shaped
structure that surrounds the glomerulus
First part of the renal tubule
Glomerular (Bowman’s) caps
Found at the cortex-medulla junction
Juxtamedullary nephrons
Extends from glomerular capsule and ends when it
empties into the collecting duct
Renal tubule
create a porous membrane—ideal for filtration
Filtration slits
Collecting ducts collect urine from both types of
nephrons, through the renal pyramids, to the calyces,
and then to the renal pelvis
Juxtamedullary nephrons
—arises from a cortical radiate artery
and feeds the glomerulus
Afferent arteriole
Nephron loop dips deep into the medulla
Juxtamedullary nephrons
Fed and drained by arterioles
Glomerulus
—receives blood that has passed
through the glomerulus
Efferent arteriole
Filtrate leaves via the
renal tubule
Specialized for filtration
Glomerulus
Urine formation is the result of three processes
- Glomerular filtration
- Tubular reabsorption
- Tubular secretion
High pressure forces fluid and solutes out of blood and
into glomerular capsule
Glomerulus
is a nonselective, passive
process in which fluid passes from the blood into
the glomerular capsule part of the renal tubule
Glomerular filtration
Water and solutes smaller than proteins are forced
through glomerular capillary walls
Proteins and blood cells are normally too large to pass
through the filtration membrane
Once in the capsule, the fluid is called
filtrate
Filtrate will be formed as long as systemic blood
pressure is normal
The peritubular capillaries reabsorb useful substances
from the renal tubule cells, such as:
Tubular reabsorption
Water
Glucose
Amino acids
Ions
If arterial blood pressure is too low, filtrate formation
stops because glomerular pressure will be too low to
form filtrate
Most reabsorption occurs in the
proximal convoluted
tubule
Some reabsorption is passive; most is active (ATP)
Reabsorption in reverse
Some materials move from the blood of the peritubular
capillaries into the renal tubules to be eliminated in
filtrate
Hydrogen and potassium ions
Creatinine
Secretion is important for:
Getting rid of substances not already in the filtrate
Removing drugs and excess ions
Maintaining acid-base balance of blood
Materials left in the renal tubule move toward the
ureter
Tubular secretion
Nitrogenous waste products are poorly reabsorbed, if
at all
Tend to remain in the filtrate and are excreted from the
body in the urine
Nitrogenous waste
—associated with creatine metabolism in
muscles
Creatinine
In 24 hours, about ___ liters of urine are
produced
1.0 to 1.8
—end product of protein breakdown
Urea
—results from nucleic acid metabolism
Uric acid
Urine is what remains after the filtrate has lost most of
its water, nutrients, and necessary ions through
reabsorption
Urine contains nitrogenous wastes and substances
that are not needed
Filtrate contains everything that blood plasma does
(except proteins)