Renal Physiology (4A) Flashcards
The three ways of substance flow in the renal system includes:
- filtration and secretion
- filtration and partial reabsorption
- filtration and complete reabsorption
Filtration only type substances include
inulin (polysaccharide, plant product that is not made by humans)
creatine (made by the breakdown of muscle metabolism and acts similar to that of insulin)
True or False: Creatine also undergoes very partial secretion
True!
Filtration and partial reabsorption substances include
electrolytes
Filtration and complete absorption substance include
glucose and amino acids
Filtration and secretion substances include
organic acids and bases such as (PAH: para-amino hippuric- acid)
Water has a percent reabsorbed of
99%
Sodium has a high amount ___ per day and a low amount of it is ___.
filtered, excreted
Sodium has a percent reabsorbed of
99.5%
Glucose is entirely ____ after it has been filtered.
reabsorbed
Urea has a ___% reabsorbed and is a waste product. It is is not all ___ into urine.
44, secreted
Reabsorption is mediated by two different types of transport including:
mediated transport (transepithelial)
diffusion across tight junctions (paracellular)
What are the minor and and major parts of reabsorption transport?
Major - mediated
Minor - diffusion
The luminal membrane of transepithelial transport faces the
tubular lumen
The basolateral membrane of transepithelial transport faces the
blood/ interstitial space (peritubular capillaries)
True or False: Active transport occurs on both sides of membrane for Na+
False
True or False: Across the luminal (apical side), the Na+ movement varies from segment to segment.
Does it depend on the type of channel or transport protein?
True, Yes
___ transport occurs in the proximal convoluted tubule on the basolateral side and is known to be ___ active transport.
Co/counter, secondary
_____ occurs via the Na+ channels in the ____.
Diffusion, cortical collecting duct
____ transport occurs across the basolateral membrane by ___ ATPase.
Active, Na+/K+
Reabsorption of Na+ in the proximal tubule from the filtrate to the interstitial fluid is done by ____ transport.
From the interstitial fluid to the plasma it occurs via ___ and ___ transport.
mediated, diffusion, bulk
How Na+ moves (2 steps)
- Na+ enters the cell through membrane proteins moving from the tubular lumen to the proximal tubule cell and is moving down it electrochemical gradient
- Na+ is pumped out of the basolateral side using secondary active transport of Na+/K+ ATPase
Bulk transport in simple definition is
lots of volume of H20 that it gets passed through the peritubular tube
Is filtrate similar to interstitial fluid?
Yes
