Renal Physio Flashcards
Wt of kidney
150g
Location of kidney
T12-L3
Aka “glomerular cells of the afferent arterioles”
JG cells
JG cells are found where
Afferent arterioles
Location of macula densa
Distal tubule
Workhorse of the tubular system
PCT
Substances that are filtered only
Inulin, creatinine
Substances that are completely reabsorbed
Glucose, amino acids
Substances that are filtered then secreted
PAH, organic acida and bases
Normal GFR
125ml/min or 180L/day
GFR/RPF
Filtration fraction
Hormone that preserves GFR
Angiotensin II
Local autoregulation occurs at BP of
75-160mmHg
Constant sodium load delivered to distal tubule
Tubuloglomerular feedback
Vasoconstricts afferent arteriole
Adenosine
Vasodilates afferent arteriole
Nitric oxide
Percentage of solute reabsorbed is held constant
Glomerulotubular balance
All substances appear in urine; all neohrons exhibit saturation
Renal transport maximum
Responsive to vasopressin
Collecting duct
Area where principal cells and intercalated cells are found
Second part of distal tubule
Site of action of aldosterone
Distal tubule
Effect of alcohol on ADH secretion
Decreases ADH secretion
Regulates glucose
Na glucose cotransport
Threshold for glucose
200mg/100ml
Glucose transport from lumen to PCT
SGLT 2
Glucose transport from PCT to peritubular capillaries
GLUT 1 and GLUT 2
Factors that shift K into cells
K AIBA- aldostorone, insulin, b adrenergic stimulation, alkalosis
Where does regulation of K occur
Late distal and cortical collecting tubules
Serves as urinary buffer for H
Unreabsorbed phosphate
Countercurrent multiplier
Loop of henle
Countercurrent exchanger
Vasa recta
where is the thirst center found?
Anterovrntral wall of 3rd ventricle and preoptic nuclei
