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Physiology > Blood > Flashcards

Blood Flashcards

0
Q

Total iron in the body

A

4-5g

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1
Q

Acts as an acid base buffer for whole blood

A

Carbonic anhydrase

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2
Q

Primary storage protein of iron in the liver

A

Ferritin

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3
Q

Secondary storage protein of iron

A

Hemosiderin

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4
Q

Transport of iron

A

Transferrin

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5
Q

Most numerous wbcs

A

Neutrophils

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6
Q

Least numerous wbcs

A

Basophils

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7
Q

Highly lobulated nucleus

A

Neutrophils

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8
Q

Bilobed nucleus, stain bright red with eosin dyr

A

Eosinophils

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9
Q

Bilobed/trilobed nucleus, largely densely basophilic(blue granules)

A

Basophils

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10
Q

Produces histamine, heparin, bradykinin, serotonin

A

Basophils

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11
Q

Largest wbc

A

Monocytes

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12
Q

Eccentrically placed nucleus

A

Monocyte

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13
Q

Life span of plateletd

A

7-10 days

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14
Q

Smallest wbc

A

Lymphocytes

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15
Q

Round densely stained nucleus with a pale basophilic non granular cytoplasm

A

Lymphocytes

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16
Q

Movement of neutrophils and macrophages

A

Ameboid

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17
Q

1st line of defense of the body

A

Tissue macrophages

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18
Q

2nd and 3rd line of defende

A

Neutrophils, monocytes

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19
Q

Adaptive immunity involves the formation of?

A

Antibodies

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20
Q

Divalent antibody

A

IgG

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21
Q

Most abundant antibody

A

IgG

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22
Q

Smallest ; secondary responses; so many

A

IgG

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23
Q

Primary immune response

A

IgM

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24
Q

Largest

A

IgM

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25
Q

Antibody that acts as an antigen receptor

A

IgD

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26
Q

Mechanism of action of antibiodies

A

Direct- agglutination, precipitation, neutralization, lysis; indirect- complement system

27
Q

Complement is reponsible for

A

Opsonization, membrane attack complex, stimulation of inflammation

28
Q

Complement responsible for opsonization

A

C3b

29
Q

Complement that is anaphylatoxin

A

C3a,4a,5a

30
Q

Complement wc is chemotactic

A

C5a

31
Q

Complement wc is part of the membrane attack complex

A

C5b -C9

32
Q

T helper cell: CD ___ and MHC ___

A

4, II

33
Q

Cytotoxic T cells: CD ___ and MHC ___

A

8 and I

34
Q

Targets virally infected cells, cancer cells, transplanted cells

A

Cytotoxic T cells

35
Q

Suppresses action of helper T and cytotoxic T cells

A

Suppressor T cells

36
Q

Activates helper t cells

A

IL 1

37
Q

Activated cytotoxic, suppressor and memory t cells

A

IL 2

38
Q

Activates B cells

A

IL 4,5,6

39
Q

Antigen found in type A blood

A

N acetyl galactosamine

40
Q

Antigen in type b bloodw

A

Galactose

41
Q

Antigen in Rh + blood

A

D antigen

42
Q

Cells responsible for graft rejection

A

T cells

43
Q

Drugs used for graft rejection

A

Glucocorticoids, azathioprine, cyclosporine

44
Q

Events in hemostasis

A

Vascular constriction, platelet plug formation, blood coagulation,

45
Q

Mechanisms for platelet plug formation

A

Platelet adhesion, platelet aggregation

46
Q

Responsible for platelet adhesion

A

vWF, glycoprotein 1b

47
Q

responsible for platelet aggregation

A

Fibrinogen, glycoprotein IIb and IIIa

48
Q

Converts prothrombin to thrombin

A

Prothrombin activator

49
Q

Converts fibrinogen to fibrin

A

Thrombin

50
Q

Important cation in blood coagulation

A

Ca

51
Q

Pathway when there is trauma to vascular walls; faster and more explosive

A

Extrinsic

52
Q

Pathway when there is trauma to blood cells or exposure to blood collagen from traumatized vessel walls

A

Intrinsic

53
Q

The extrinsic pathway is initiated by

A

Tissue factor

54
Q

Extrinsic pathway involves wc clotting factors

A

V, VII, X

55
Q

thrombin causes a positive feedback by activation of wc clotting factor

A

v

56
Q

Intrinsic pathway is initiated by

A

Factor XII and platelets

57
Q

Clotting factors involved in intrinsic pathway

A

8,9,11,12

58
Q

Clotting factors common to both intrinsic and extrinsic pathway

A

V,X

59
Q

Hemophilia A is due to a deficiency in

A

Factor VIII

60
Q

Hemophilia B is due to a deficiency in

A

IX

61
Q

Hemophilia C is due to a deficiency in

A

XI

62
Q

Hageman factor

A

XII

63
Q

Calcium is factor?

A

IV

64
Q

Stuart factor

A

X

65
Q

Converts plasminogen to plasmin

A

Tissue plasminogen activator

Physiology (22 decks)

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