Neurotransmitters Flashcards

0
Q

Synthesis of Ach uses

A

Acetyl Coa and choline

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1
Q

Acetylcholine is secreted where

A

Nucleus Basalis of Meynert (mACH- meynert, muscarinic)

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2
Q

Enzyme that degrades Ach

A

Acetylcholinesterase

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3
Q

Associated with ach deficiency

A

Alzheimer’s

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4
Q

Dopamin is found where

A

Substantia nigra para compacta and ventral tegmental area (dope)

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5
Q

Dopamine is degraded by

A

MAOI and COMT

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6
Q

Where is serotonin produced

A

Median raphe

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7
Q

Wc catecholamine has stronger B2 effect

A

Epinephrine

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8
Q

Where is NE produced

A

ILOCUS NORte (Locus ceruleus, NORepinephrine)

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9
Q

Inhibitor of pain pathway

A

Serotonin (sero pain)

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10
Q

Happy hormone

A

Serotonin

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11
Q

Where is serotonin converted to melatonin

A

Pineal gland

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12
Q

Resting membrane potential is caused by

A

Nernst potential for Na and K diffusion, Na-K leak channels, Na-K-ATPase pump

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13
Q

What is Threshold

A

When Na influx > K leak/Efflux

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14
Q

Undershoot is caused by

A

Prolonged opening of K channels

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15
Q

Where do you get tetradotoxin

A

Puffer fish

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16
Q

Where do you get saxitoxin

A

Mussels (dinoflagellates)

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17
Q

Example of potassium channel blocker

A

Tetraethylammoniun (puffer fish)

18
Q

Ionic basis for absolute refractory period

A

Closure of Na inactivation gates

19
Q

Ionic basis for relative refractory period

A

Prolonged opening of K channels (POK- eR (relative))

20
Q

When a cell is depolarized so SLOWLY such that the theshold potential is passed without firing an action potential

A

Accomodation

21
Q

Where is ADH secreted

A

Supraoptic nuclei of the hypothalamus

22
Q

ADH responds to ECF changes detected by osmoreceptors found where

A

Organum vasculosum (OrgasOSM)

23
Q

Where is oxytocin produced

A

Paraventricular nuclei of hypothalamus

24
Q

Most comon causr of elderly dementia

A

Alzheimer’s

25
Q

Dopamine deficiency leads to

A

Parkinsons

26
Q

Dopamine excess leads to

A

Schizophrenia

27
Q

Long term behavior and memory

A

Nitric oxide

28
Q

Nitric oxide is from?

A

ArgiNIne (argentiNO)

29
Q

Histamine is from

A

Histidine

30
Q

Histamine is located where

A

Tuberomamillary nucleus of the hypothalamus

31
Q

Involved in control of arousal, sleedp and circadian rhythm

A

Histamine

32
Q

GlycINE is flound where

A

Spinal interneurons (glyc+ (sp)INE= glycINE)

33
Q

Function of glycine

A

Increases chloride influx(inhibitory)

34
Q

Number 1 inhibitory neurotransmitter in the brain

A

GABA

35
Q

GABA is derived from

A

Glutamate

36
Q

Function of GABA

A

A- chloride influx ; B- potassium efflux

37
Q

Excitatory NT in brain

A

Glutamate

38
Q

Inhibit neurons in the brain, involved in perception of pain

A

Enkephaljn, endorphin, dynorphin

39
Q

Pain transmission

A

Substance P (substance pain)

40
Q

Potential difference that exist across the membrane

A

Resting membrane potential

41
Q

Typical resting membrane potential value

A

-70mV

42
Q

Time periods in an action potential during wc new stimulus cannot be readily elicited

A

Refractory period