Renal cell carcinoma/ Wilms Tumour / Bladder Cancer Flashcards
What are the RF for renal cell carcinoma
Smoking
40+
Haemodyalysis
Von Hippellindau
What is Von Hippellindau
Aut Dom loss of tumour supressor gene
Px = Bilateral RCC -> Cysts and cerebellum cancers
What is the main triad of symptoms typical of RCC
Flank pain
Haematuria
Abdo mass
(May have varicocele)
What is the 1st line investigation for RCC
USS
What is the gold standard investigation for RCC
CT CAP
What is the staging used in RCC
Robson 1-4
How can RCC be treated
Nephrectomy
-Partial for bilateral RCC
If MET = Biologics/IFN-d
What is Wilm’s Tumour
Renal mesenchymal stem cell tumour in children
Nephroblastoma
What cells are affected in Wilm’s Tumour
Mesenchymal stem cells
What type of cancer is bladder cancer
Transitional cell carcinoma of bladder
What type of epithelium lines the bladder
Transitional epithelium/Urothelium
What are the risk factors for TCT/Bladder cancer
THINK MALE PAINTING SMOKER
-Especially 2-Naphtylamine
Chemo and Radio
What is the main sign of bladder cancer
Painless haematuria
How can TCC/Bladder cancer be diagnosed
Flexible Cystoscopy w/ Biopsy
How can TCC/bladder cancer be managed
TURBT/Cystectomy
Chemo
Palliative
If a patient has schistomiasis, what cancer are they most likely to have
Squamous cell carcinoma>TCT
What is the most common GU cancer
Renal cell Carcinoma in 40+
What is the prevalence of TCC, SCC and Adenocarcinoma
Transitional = MC
Squamous
Adenocarcinoma = LC
What is Wim’s tumour also known as
Nephroblastoma
What paraneoplastic syndrome presents in Renal cell carcinoma
Stauffer syndrome
Px = chloestasis and hepatosplenomegaly
2nd to raised IL6
What is the histology of Renal cell carcinoma
Clear cells
What is Wilm’s tumour associcated with
Bechwith-Wiederman
Px = macroglossia, macrosomia and neonatal hyperglycemia
