Nephrotic Syndrome Flashcards
What are the primary Nephrotic syndromes
Minimal Change disease
Focal Segmental Glomerulosclerosis
Membronous Nephropathy
What is a secondary nephrotic syndrome
Diabetic Nephropathy
What is the most common Nephrotic syndrome in children
Minimal Change Disease
What is the most common Nephrotic syndrome in adults
Caucasian = Membronous Nephropathy Other = Focal Segemental Glomerulosclerosis
How does nePHrOtic syndrome present
Proeteinuria
Hypoalbuminemia / Hyperlipidemia = Weight gain
Oedema
What is the investigation used in Nephrotic syndromes
Biopsy w/Microscopy
In minimal change what can be seen in a light microscope
No Change
What feature of Minimal Change in found in an electron microscope
Podocyte effacement w/ Fusion
What is the feature of Focal SEGEMENTAL glomeruloSCLEROSIS in light microscope
Segemental sclerosis
In membranous Nephropathy, what can be seen in light and electron microscope
Light = Thick Glomeuralr Basement Membrane Electron = Subpodocyte Immune complex deposition "Spike and Dome"
How are nephrotic syndromes treated
Steroids for 12 weeks
Best for minimal change
What disease shows podocyte effacement in electron microscope
Minimal Change
What disease presents with Segmental sclerosis @light microscope
Focal Segmental Sclerosis
