Nephritic Syndrome Flashcards
What diseases are Nephritic
IgA Nephropathy (T3) Post Strep GN (T3) SLE (T3) Haemolytic Uremic Syndrome (T3) Goodpastures (T2) T = HYPERSENSITIVITY
What hypersensitivity are nephritic syndromes
T3 except Goodpastures = T2
What is IgA Nephropathy
IgA complex deposition presenting 1-2 days after viral tonsilitis/Gastroenteritis infection
How does IgA nephropathy present in patient
Visible Ribena Hameaturia
Small cell vasculitis (Henloch Purpura) presents the same as IgA except for what difference
IgA = Only kidney deposition HSP = Systemic deposition
How is IgA investigated
IgA complex deposition w/ Immunoflurosecence
How is IgA Managed
BP control w/ACE-i
How does Post strep GN present
AKI
Oedema
HTN
Specks of haematuria
When does Post strep GN present
2 weeks after pharyngitis from Group A/B haemolytic strep (Strep Throat w/ Strep Pyo)
How is Post strep GN Investigated
Light microscope = Hypercellular glomeruli
Electron microscope = Subpodocyte immune complex deposition
Immunofluorsecen = Starry sky appearance (Ig, c3 and Magnesium on GBM)
Post strep management?
Sel limiting but can progress to RPGN
What is Lupus Nephritis
Renal impairment second to SLE (ANA in endothelium)
How is lupus nephritis investigated
ANA Positive
Anti dsDNA positive
How is lupus nephritis treated
Steroids
Hydroxychloroquine
Immunosuppressants
What is Good pastures
Auto Anti-GBM causes GN and Pulmonary/Alveolar haemorrhage
