Renal ADE for each class Flashcards
Which drug class can cause chronic renal impairment if used for a long time?
A) Opioids
B) Statins
C) Nonsteroidal anti-inflammatory agents
D) Metformin
C) Nonsteroidal anti-inflammatory agents
Rationale: Long-term use of nonsteroidal anti-inflammatory agents can lead to chronic renal impairment.
Which drug is recognized as a risk factor for acute kidney injury in older people?
A) Fibrates
B) Statin
C) Metformin
D) Proton pump inhibitor
B) Statin
Rationale: Statins are recognized as a risk factor for acute kidney injury in the elderly.
Which drug causes a reversible rise in serum creatinine values?
A) Fibrates
B) Opioids
C) Proton pump inhibitors
D) Aminoglycosides
A) Fibrates
Rationale: The adverse effect of fibrates is a reversible rise in serum creatinine values.
Which antibiotic can lead to allergic interstitial nephritis, a type III hypersensitivity reaction?
A) Aminoglycosides
B) Fluoroquinolones
C) Tetracycline
D) Vancomycin
B) Fluoroquinolones
Rationale: Fluoroquinolones can cause allergic interstitial nephritis, a type III hypersensitivity reaction.
Which drug is associated with nephrotoxicity after a single dose but recovers kidney function after cessation?
A) Aminoglycosides
B) Metformin
C) Opioids
D) Fibrates
A) Aminoglycosides
Rationale: Aminoglycosides can cause nephrotoxicity with a single dose, but kidney function typically recovers after cessation.
Which drug class can lead to acute interstitial nephritis in acute settings?
A) Proton pump inhibitors
B) Opioids
C) Nonsteroidal anti-inflammatory agents
D) Statins
C) Nonsteroidal anti-inflammatory agents
Rationale: In acute settings, nonsteroidal anti-inflammatory agents can lead to acute interstitial nephritis.
Which drug has a role in decreasing proteinuria in diabetic nephropathy patients?
A) Doxycycline
B) Vancomycin
C) Metformin
D) Aminoglycosides
A) Doxycycline
Rationale: Doxycycline, a type of tetracycline, has a role in decreasing proteinuria in diabetic nephropathy patients.
Which drug is a protein synthesis inhibitor?
A) Aminoglycosides
B) Tetracycline
C) Fibrates
D) Opioids
B) Tetracycline
Rationale: Tetracycline is a protein synthesis inhibitor.
Which drug class can cause acute kidney injury, chronic kidney injury, and end-stage renal disease?
A) Proton pump inhibitors
B) Statins
C) Opioids
D) Fibrates
A) Proton pump inhibitors
Rationale: Proton pump inhibitors can cause drug-induced allergic interstitial nephritis, acute kidney injury, chronic kidney injury, and end-stage renal disease.
Which drug should have its dose adjusted in patients with kidney impairment to prevent accumulation?
A) Aminoglycosides
B) Metformin
C) Opioids
D) Statins
B) Metformin
Rationale: In patients with kidney impairment, it’s preferable to adjust the dose of metformin so it doesn’t accumulate.
Which drug is associated with Vancomycin-induced nephrotoxicity?
A) Metformin
B) Tetracycline
C) Aminoglycosides
D) Vancomycin
D) Vancomycin
Rationale: Vancomycin is associated with Vancomycin-induced nephrotoxicity.
Which drug class, when used concomitantly with quinolone antibiotics, may increase the risk of seizures?
A) Proton pump inhibitors
B) Nonsteroidal anti-inflammatory agents
C) Opioids
D) Statins
B) Nonsteroidal anti-inflammatory agents
Rationale: Nonsteroidal anti-inflammatory agents, when used with quinolone antibiotics, may increase the risk of seizures.
Which drug’s long-term usage results in albuminuria?
A) Opioids
B) Statins
C) Fibrates
D) Metformin
A) Opioids
Rationale: Long-term usage of opioids can result in albuminuria.
Which antibiotic is known to cause nephrotoxicity but recovers kidney function within 20 days of cessation?
A) Tetracycline
B) Aminoglycosides
C) Fluoroquinolones
D) Vancomycin
B) Aminoglycosides
Rationale: Aminoglycosides can cause nephrotoxicity, but kidney function typically recovers within 20 days of cessation.
Which drug is a cell wall synthesis inhibitor?
A) Doxycycline
B) Aminoglycosides
C) Vancomycin
D) Fibrates
C) Vancomycin
Rationale: Vancomycin is a cell wall synthesis inhibitor.
Which drug class can lead to a reversible rise in serum creatinine values?
A) Opioids
B) Statins
C) Fibrates
D) Proton pump inhibitors
C) Fibrates
Rationale: Fibrates can cause a reversible rise in serum creatinine values.
Which drug can cause allergic interstitial nephritis within one week to two months of discontinuation?
A) Fluoroquinolones
B) Aminoglycosides
C) Tetracycline
D) Metformin
A) Fluoroquinolones
Rationale: Fluoroquinolones can cause allergic interstitial nephritis, and most cases resolve within one week to two months of discontinuation.
Which drug is associated with decreasing proteinuria in diabetic nephropathy patients?
A) Doxycycline
B) Vancomycin
C) Aminoglycosides
D) Fibrates
A) Doxycycline
Rationale: Doxycycline has a role in decreasing proteinuria in diabetic nephropathy patients.
Which drug class can cause acute interstitial nephritis in acute settings?
A) Statins
B) Opioids
C) Proton pump inhibitors
D) Nonsteroidal anti-inflammatory agents
D) Nonsteroidal anti-inflammatory agents
Rationale: In acute settings, nonsteroidal anti-inflammatory agents can lead to acute interstitial nephritis.
Which drug should be dose-adjusted in patients with kidney impairment to avoid accumulation?
A) Opioids
B) Metformin
C) Aminoglycosides
D) Statins
B) Metformin
Rationale: In patients with kidney impairment, it’s preferable to adjust the dose of metformin so it doesn’t accumulate.
Which drug class, when used with nonsteroidal anti-inflammatory agents, may enhance the neuroexcitatory effect?
A) Quinolones
B) Opioids
C) Statins
D) Proton pump inhibitors
A) Quinolones
Rationale: Quinolones may enhance the neuroexcitatory effect when used concomitantly with nonsteroidal anti-inflammatory agents.
Which drug class can cause drug-induced allergic interstitial nephritis?
A) Proton pump inhibitors
B) Fibrates
C) Opioids
D) Statins
A) Proton pump inhibitors
Rationale: Proton pump inhibitors can cause drug-induced allergic interstitial nephritis.
Which antibiotic is a protein synthesis inhibitor?
A) Aminoglycosides
B) Fluoroquinolones
C) Tetracycline
D) Vancomycin
C) Tetracycline
Rationale: Tetracycline is a protein synthesis inhibitor.
Which drug is associated with an increased risk of seizure when used with nonsteroidal anti-inflammatory agents?
A) Quinolones
B) Metformin
C) Opioids
D) Statins
A) Quinolones
Rationale: Quinolones have an increased risk of seizure when used concomitantly with nonsteroidal anti-inflammatory agents.
Which drug class can cause chronic kidney injury and end-stage renal disease?
A) Proton pump inhibitors
B) Opioids
C) Fibrates
D) Statins
A) Proton pump inhibitors
Rationale: Proton pump inhibitors can cause chronic kidney injury and end-stage renal disease.
Which drug class can lead to albuminuria with long-term use?
A) Opioids
B) Statins
C) Nonsteroidal anti-inflammatory agents
D) Proton pump inhibitors
A) Opioids
Rationale: Long-term usage of opioids can lead to albuminuria.
Which drug class is recognized as a risk factor for acute kidney injury in the elderly?
A) Opioids
B) Statins
C) Fibrates
D) Proton pump inhibitors
B) Statins
Rationale: Statins are recognized as a risk factor for acute kidney injury in the elderly.
Which drug class can cause a reversible rise in serum creatinine values?
A) Opioids
B) Statins
C) Fibrates
D) Proton pump inhibitors
C) Fibrates
Rationale: Fibrates can cause a reversible rise in serum creatinine values.
Which antibiotic can cause nephrotoxicity but recovers kidney function within 20 days of cessation?
A) Tetracycline
B) Aminoglycosides
C) Fluoroquinolones
D) Vancomycin
B) Aminoglycosides
Rationale: Aminoglycosides can cause nephrotoxicity, but kidney function typically recovers within 20 days of cessation.
Which drug should be dose-adjusted in patients with kidney impairment to avoid accumulation?
A) Opioids
B) Metformin
C) Aminoglycosides
D) Statins
B) Metformin
Rationale: In patients with kidney impairment, it’s preferable to adjust the dose of metformin so it doesn’t accumulate.
