renal Flashcards
HUS symptoms
thrombocytopenia, anemia, and acute renal failure
treatment for HUS
dialysis
Electron microscope findings of acute poststreptococcal glomerulonephritis
subepithelial humps from immune complex deposition
poststreptococcal glomerulonephritis presentation
young child with dark urine, periorbital edema, proteinuria
lab findings poststreptococcal glomerulonephritis
positive antistreptolysin o titer, RBC casts in urine, decreased levels of complement
what type of hypersensitivity reaction is poststreptococcal glomerulonephritits
type III
EM findings of membranoproliferative glomerulonephritis
subendothelial immune complex deposition (C3 and IgG)
IF findings of membranoproliferative glomerulonephritis
granular appearing from immune complexes
H & E stain of membranoproliferative glomerulonephritis
tram-track appearance due to splitting of the basement memrane with mesangial proliferation
differentiation between type 1 and 2 of membranoproliferative glomerulonephritis
type II membranoproliferative glomerulonephritis will have the presence of C3 nephritic factor leading to dense deposit disease
what does C3 nephritic factor do?
stabilizes C3 convertase so type II membranoproliferative glomerulonephritis pts will have low C3 levels