pharm

Question 1

Clonidine MOA

Answer 1

alpha 2 agonist, acts centrally on GCPR –> Gi

Question 2

clonidine indication

Answer 2

rebound HTN, last resort drug

Question 3

clonidine application

Answer 3

transdermal

Question 4

clonidine ADE

Answer 4

rebound HTN (must taper pt off), 
dry mouth, sedation (central acting)

Question 5

Ritonavir, bocepravir, telapravir MOA

Answer 5

protease inhibitor

Question 6

ritonavir indication

Answer 6

HIV

Question 7

telapravir indication

Answer 7

Hepatitis C

Question 8

protease inhibitor ADE

Answer 8

lipodystrophy, hyperglycemia, hyperlipidemia, hyperinsulinemia, GI intolerance

Question 9

Mainstay of treatment for COPD

Answer 9

bronchodilators

Question 10

albuterol MOA

Answer 10

short acting beta2 agonist

Question 11

albuterol ADE

Answer 11

tremors, tachycardia, hypokalemia (increased Na/K ATPase activity)

Question 12

1st line treatment of trichomoniasis

Answer 12

metornidazole

Question 13

1st line treatment of bacterial vaginosis

Answer 13

metronidazole

Question 14

loop diurectics MOA

Answer 14

inhibit the Na/K/Cl channel in the thick ascending limb of the loop of henle

Question 15

loop diuretics

Answer 15

furosemide, Torasemide, Bumetanide

Question 16

griseofulvin indication

Answer 16

taken orally for superficial fungal infections: used for tinea and ringworm

Question 17

griseofulvin ADEs

Answer 17

CYP P450 induction, espcially with warfarin –> decreases the efficacy and half life of other drugs
teratogenic, carcinogenic

Question 18

griseofulvin MOA

Answer 18

interferes with microtubules and disrupts mitosis

Question 19

main ADE of steroid therapy

Answer 19

cushinoid syndrome: buffalo hump and moon facies, insulin resistance, red face, abdominal striae, osteoporosis (hip fractures)

Question 20

Special incidences where you would use a Cox-2 specific inhibitor

Answer 20

to control inflammation in patients with high GI risk but low risk of CV incident

Question 21

Amiodarone MOA

Answer 21

blocks K channels, prolonging depolarization

Question 22

amiodarone important ADE

Answer 22

pulmonary fibrosis

Question 23

what class of antiarrhythmic is amiodarone

Answer 23

class III

Question 24

albenzadol indication

Answer 24

parasitic worm infections such as pinworms and hook worms

Question 25

albenzadol MOA

Answer 25

stabilizes MTs and inhibits cellular division in the M phase