pulmnology

Question 1

CO poisoning symptoms

Answer 1

HA, dizziness, nausea, bright red complexion

Question 2

tx for CO poisoning

Answer 2

100% hyperbaric O2 or high flow O2

Question 3

effect of CO on the O2 dissociation curve

Answer 3

left shift –> CO has increased affinity of hgb (greater than O2) will bind more tightly to Hgb –> carboxyhemoglobin

Question 4

Cystic Fibrosis–> most common mutation

Answer 4

Deletion of Phe508 on chromosome 7; 1 AA deletion causing a defect in the transport of CFTR to the cell surface

Question 5

Inheritance patter of CF

Answer 5

autosomal recessive

Question 6

Sarcoidosis etiology

Answer 6

nonsmoking AA female in her 30s

Question 7

MC sarcoidosis lab finding

Answer 7

Hypercalcemia

Question 8

restrictive lung disease PFTs

Answer 8

decreased TLC, FVC, RV, and Diffusion capacity, low/normal FEV1
Elevated or normal FEV1:FVC ratio

Question 9

Tx of sarcoidosis

Answer 9

corticosteroids

Question 10

Presentation of sarcoidosis

Answer 10

weight loss, dyspnea, fever

Question 11

Histologic hallmark of sarcoid

Answer 11

noncaseating granulomas with epitheliod cells and CD4 T cells

Question 12

lab findings of sarcoidosis

Answer 12

hypercalcemia and hypercalciuria

Question 13

clinical findings of sarcoidosis

Answer 13

bilateral hilar LAD, hypercalcemia, abn PFTs

Question 14

pathogenesis of hypercalcemia in sarcoidosis

Answer 14

Macrophages are overexpressing 1-alpha-hydroxylase –>increased vit D-1,25 activation –> increased absorption of Ca and reabsorption of PO4, inhibition of PTH

Question 15

most common cause of common cold

Answer 15

rhinovirus

Question 16

what time of sensitivity reaction is the TB skin test?

Answer 16

type IV