Renal Flashcards
Differential for acute renal failure days after transplant (2)
Acute graft failure
Post transplant lymphoproliferative disorder
PTLD
- pathology
- management
Clonal T/B cell population
Lymphoid cells
Can be EBV positive
Mx: reduce immunosuppression +- chemo
Management of acute graft rejection
IV steroids
Focal Segmental Glomerulosclerosis
- classification
- pathology
- management
1y = nil obvious cause found
2y = HIV, heroin use
Scarring seen sparingly, only in a few parts of the glomerulus
Mx: steroids
Absolute contra-indications to being a living kidney donor (6)
Uncontrolled BP (defined as not controlled on >3 agents)
Active malignancy
Chronic infection
Proteinuria
Bilateral renal artery atherosclerosis
Sickle cell disease
Post-streptococcal GN
- alternative name
- pathology
Acute diffuse proliferative GN
See sub-epithelial humps, may have a starry sky appearance
Young
Abdominal pain worse after eating and haematuria
Lack of collateral supplies on angiogram
Polyarteritis Nodosa
Linear deposition IgG along glomerular capillaries
Anti-GBM disease
- can be post-transplant in patients with Alport’s syndrome
Deciding on epo delivery
Give SC if pre-dialysis
Give IV if on dialysis
1st line management over active bladder/mixed incontinence
Tolteradine
IgA vs streptococcal GN
Days vs Weeks
Large muscle mass
- what can you use to estimate eGFR?
Cystatin-C
Management of Goodpasture’s Syndrome
Steroids
Cyclophosphamide
Plasmophoresis
Gitelmann’s VS Bartter’s Syndrome
Normotension, hypokalaemia
G = hypocalciuria (thiazide channel affected, distal convoluted tubule)
B = hypercalciuria (ascending loop)
Focal segmental sclerosis
Effacement of foot process
FSGS
Hypokalaemia
HTN
Low renin
Low/normal aldosterone
- management
Liddle’s Syndrome
Mx: amiloride
What GN has the highest rate of recurrence?
Membranoproliferative GN
Which RTA is associated with calcium stones?
T1 RTA (distal)
