Renal Flashcards
What is goldblatt’s kidney?
Flea-bitten kidney (blown capillaries)
What is Uremia?
Azotemia + symptoms
What is Azotemia?
^ BUN / Cr
What is Nephritic kidney disease?
^ size of fenestrations => vasculitis
What is nephrotic kidney disease?
Lost BM charge due to deposition on heparin sulfate => massive proteinuria and lipiduria
What is seen in RPGN (Rapidly Progressive Glomerulonephritis)?
Crescents
What is Post-Strep GN?
Subepithelial, IgG/C3/C4 deposition, ASO Ab
What is Interstitial Nephritis?
Urine eosinophils
What is Lupus nephritis?
Subepithelial
What is MGN (membranoglomerulonephritis)?
Deposition
What is MPGN (Membranoproliferative glomerulonephritis)?
Tram-tracks (type II has low C3)
What is MCD (Minimal Change Disease)?
Kids, fused foot processes, no renal failure, loss of charge barrier
What is FSGS (Focal segmental Glomerulosclerosis)?
AA, HIV pts
What are the vasculitis w/ low C3?
“PMS in Salt Lake City”
Post-strep GN MPGN type II SBE Serum sickness Lupus Cryoglobulinemia
What is the most common cause of kidney stones?
Dehydration
What are the most common type of kidney stones?
Calcium pyrophosphate
What type of kidney stones have coffin-lid crystals?
Triple phosphate
What type of kidney stones have rosette crystals?
Uric acid
What type of stones have hexagonal crystals?
Oxalate
Which part of the nephron concentrates urine?
Medulla
What disease has Aniridia?
Wilm’s Tumor
What disease has Iridocyclitis?
Juvenile rheumatoid arthritis
What is Phimosis?
Foreskin scarred at penis head (foreskin stuck smooshed up)
What is Paraphimosis?
Foreskin scarred at penis base (retraction of foreskin => strangulates penis)
What is urge incontinence?
Urgency leads to complete voiding (detrusor spacity –> small bladder volume)
What is stress incontinence?
Weak pelvic floor muscles (estrogen effect)
what is overflow incontinence?
runs down leg but can’t complete empty bladder
what structures have one-way valves?
urethra, ejaculatory duct
What structore have fake sphincters?
Ureters, LES, Ileocecal valve
What has WBC casts?
Nephritis
What has WBC casts only?
Pyelonephritis (sepsis)
What has WBC = eosinophils?
Interstitial nephritis (allergies)
What has WBC casts + RBC casts?
Gomerulonephritis
What has fat casts?
nephrotic syndrome
what has waxy casts?
chronic renal failure
what has tubular casts?
ATN (Acute Tubular Necrosis)
what has muddy brown casts?
ATN (acute Tubular Necrosis)
what has hyaline casts?
normal sloughing
what has epithelial casts?
normal sloughing
what has crescents?
RPGN
How do you measure afferent renal function?
Creatinine (or inulin)
How do you measure efferent renal function?
BUN (or PAH)
What is the afferent arteriole’s job?
Filter
What is the efferent arteriole’s job?
Secrete
How do you test afferent arteriole function?
GFR
How do you test efferent arteriole function?
RPF
What is pre renal failure?
Low flow to kidney (BUN:Cr>20)
What is renal failure?
Damage glomerulus (BUN:Cr <20)
What is post renal failure?
Obstruction (havent peed in last 4 days)
What is the job of the proximal tubule?
Reabsorb glucose, amino acids, salt, bicarb
What is the job of the thin ascending limb?
Reabsorb water
What is the job of the thick ascending limb?
Make the concentration gradient by reabsorbing Na, K, Cl, Mg, Ca without water
What is the job of the early distal tubule?
Concentrate urine by reabsorbing NaCl (hypotonic)
What is the job of the late distal tubule?
Final concentration of urine by reabsorbing water, excretion of acid (isotonic)
What does the macula densa do?
Measures osmolarity
What does the J-G apparatus do?
Measures volume
What is Fanconi’s syndrome?
Old tetracycline use => urine phosphates, glucose, amino acids
What is Bartter’s syndrome?
Baby w/ defective triple transporter (low Na, Cl, K w/normal BP)
What is Psychogenic polydipsia?
No concentrating ability -> cerebral edema
What is hepatorenal syndrome?
High urea from liver -> increase glutaminase -> NH4 -> GABA -> kidney stops working
What is. Type1 RTA?
Distal renal tubular acidosis: H/K in CD is broken -> high urine pH (UTI, stones, Li)
What is type 2 RTA?
Proximal RTA:bad CA-> lost all bicarb -> low urine pH (multiple myeloma)
What is type 3 RTA?
RTA I + RTA II -> normal urine pH (5-6)
What is type 4 RTA?
Infarct J-G -> no renin -> no Aldo -> high k (DM, NSAIDs, ACE I, Heparin)
What is Central pontine myelinolysis?
Due to correcting Na faster than 0.5mEq/hr