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Drug Cards > Remifentanil > Flashcards

Remifentanil Flashcards

Please note that the drug card information is for Educational Use ONLY, and the source is from Carrie Bowman's glossary of drug cards permitted by use of Georgetown NAP students. No permission is given to use these cards for anything other than as a study resource for our program.

1
Q

What is the trade name of Remifentanil?

A

Ultiva

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2
Q

What is the formal drug class of Remifentanil?

A

synthetic mu-opioid agonist

piperidine-derived with an ester link

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3
Q

What is different about the metabolism of Remifentanil?

A

-ester linkage and the resultant ultra- rapid metabolism of this drug make it unique among the opioids

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4
Q

What are the uses of Remifentanil?

A
  • analgesic during GA, in which quick onset and offset of effect is desired
  • used for suppression of transient sympathetic nervous system response to direct laryngoscopy and tracheal intubation
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5
Q

How is Remifentanil metabolized?

A
  • undergoes rapid metabolism by nonspecific plasma and tissue esterases
  • metabolized to inactive metabolites excreted by the kidneys
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6
Q

Is Remifentanil metabolized by pseudocholinesterases?

A

NO; therefore clearance is not affected by cholinesterase deficiency

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7
Q

What is the onset of action of Remifentanil?

A

1 - 3 minutes

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8
Q

When is the peak of Remifentanil?

A

1.5 - 2 minutes

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9
Q

What is the DOA of Remifentanil?

A

7 - 12 minutes

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10
Q

What is the elimination 1/2 life of Remifentanil?

A

10 minutes

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11
Q

What is the clearance of Remifentanil?

A

3 - 5 L/min

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12
Q

What is the Vd?

A

0.3 - 0.5 L/kg ~25mL in adults

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13
Q

Is Remifentanil protein bound?

A

66-93%

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14
Q

What is the induction infusion dosage of Remifentanil?

A

0.5 - 1 mcg/kg over 60-90 seconds

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15
Q

What is the addnal bolus dose of Remifentanil?

A

0.1 - 1 mcg/kg

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16
Q

What is the maintenacne infusion rate of Remifentanil?

A

0.1 -1 mcg/kg/min

17
Q

What is the loading dose of Remifentanil?

A

1 -2 mcg/kg

18
Q

What is the dose of Remifentanil?

A

1 -2 mcg/kg

19
Q

What is the Infusion rate of Remi?

A

0.05 - 0.25 mcg/kg/min

20
Q

What is unique about Remifentanil?

A

chemically r/t fentanyl but has ester linkage

21
Q

What is unique about Remifentanil’s Vd?

A

VERY SMALL Vd, minimal accumulation in tissues, even with infusion

22
Q

What is the potency of Remifentanil similar to?

A

Potency similar to fentanyl; 100 times more potent than morphine

23
Q

What is the clinical significance of Remifentanil?

A
  • used to blunt noxious stimulus

- infusions for interm/long surgeries where rapid recovery is desired such as neurosurgery, O/P surgery

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