Isoproterenol

Question 1

What is the trade name of Isoproterenol?

Answer 1

Isuprel

Question 2

What is the drug classification of Isoproterenol?

Answer 2

Synthetic catecholamine, selective for beta adrenergic receptors

Question 3

What are the primary uses of Isoproterenol?

Answer 3

• chronotropic agent for heart transplant
• “chemical pacemaker” for heart block and bradydysrhythmias
• mild pulmonary vasodilating effects (reduce PulmVR)

Question 4

What is the MOA of Isoproterenol?

Answer 4

Provides non-selective beta-adrenergic stimulation of Beta 1 > Beta 2
-also a pulmonary and systemic vasodilator
-activates beta adrenergic receptors via G protein coupled receptors.
Increases HR and contractility, with decreased SVR (Increased SBP; decreased DBP and MAP)

Question 5

How is Isoproterenol metabolized and eliminated?

Answer 5

• rapidly metabolized in the liver by COMT (need infusion!)

- 40-50% eliminated unchanged in the kidneys

Question 6

What is the typical dose for Isoproterenol?

Answer 6

1-5mcg/min (infusion 0.5-10mcg/min)

Question 7

When should you avoid Isoproterenol?

Answer 7

CAD!

Question 8

What is the e 1/2 life of Isoproterenol?

Answer 8

2.5-5 minutes

Question 9

What is the onset and DOA of Isoproterenol?

Answer 9

Onset: immediate
DOA: 5-10 minutes

Question 10

What are the side effects of Isoproterenol?

Answer 10

• tachycardia
• dysrhythmias
• decreased coronary BF 2dary to decreased DBP
• increased oxygen consumption d/t inotrope and chronotrope effects
• peripheral vasodilation and hypotension

Question 11

What are the contraindications to Isoproterenol?

Answer 11

• Hypersensitivity
• Tachycardia caused by Dig toxicity
• CAD and angina

Question 12

What are the drug interactions with Isoproterenol?

Answer 12

increased potential for arrhythmias with some general anesthetics and co-administration of other sympathomimetics