remainder of chapter 3 Flashcards
gives rise to an mRNA that is never transcribed,
pseudogenes
a large portion of the human genome has ______with other species
orthologous genes
top down approach for mutagenic screening of heritable changes
classical genetic analysis
bottom up approach for specific gene is altered and phenotypic result is examined
reverse genetics
short RNAs that form a complex with mRNA which is then recognized and degraded
RNAi
repetitive parts of the DNA in organisms other than humans can be used to target specific sequences
Transposons
active in humans and give rise to mRNA
retrotranposons
mutations in these genes cause changes in all circadian behaviors generated by the internal clock
period or per
per is essential for
rhythmic behavior
when are levels of PER the highest
after dusk and during the night
when are levels of PER the lowest
early morning
clock gene regulates two properties of circadian rhythm
the length of the circadian rhythm
persistence of rhythmic in the absence of sensory input
mouse clock and fly per genes share a domain called the
PAS domain
CLOCK is highest at what time of the day
middle of the day
____activates ____transcription while ____represses _____function
CLOCK
PER
PER
CLOCK
oscillation of circadian rhythm genes can be reset by what
light
this gene encodes a signal transduction enzyme, a protein kinase activated by the cellular metabolite cyclic guanosine 3’-5’ monophosphate (cGMP)
for gene
neuropeptides ____and ____ stimulate mammalian affiliation behaviors such as pair bonding and parental bonding with offspring
oxytocin and vasopressin
in prarie vols V1a is expressed highly in which area of the brain
ventral pallidum
in montane vols V1a is expressed highly in which part of the brain
lateral septum
what gene is mutated in angelmans sydrome
ube3a
angelmans syndrome is only derived from the
maternally derived chromosome (cannot get from father)
when an mRNA is expressed from only one of the two autosome copies
parental imprinting
prader-willi syndrome is only derived from the
paternally derived chromosome (cannot get from mother)
mutation of DCX protein causes what
double cortex syndrome
