Regulation of Fatty acid synthesis

Question 1

In which organ does fatty acid synthesis take place

Answer 1

the liver

Question 2

In which subcellular location does fatty acid synthesis take place

Answer 2

the cytosol

Question 3

Acetyl COA carboxylase reaction

Answer 3

acetyl COA –> malonyl COA

Question 4

requirements to make acetyl COA carboxylase work?

Answer 4

ABC :
ATP
Biotin
CO2

Question 5

ACC1 function

Answer 5

generates malonyl COA to be used in fatty acid synthesis

Question 6

ACC2 function

Answer 6

generates malonyl COA that inhibits CPT1 and thus B-oxidation of fatty acids

Question 7

2 pathways that generate NADPH

Answer 7

1. pentose phosphate pathway

2. malic enzyme pathway

Question 8

NADPH is used for

Answer 8

biosynthesis

Question 9

NADH is used for

Answer 9

generation of ATP

Question 10

rate limiting step of Fatty acid synthesis

Answer 10

acetyl COA carboxylase reaction

acetyl coa –> malonyl coa

Question 11

fatty acid synthesis starts from which two molecules

Answer 11

1. glucose

2. amino acids (only a little bit but still happens)

Question 12

1st step of fatty acid synthesis

Answer 12

pyruvate –> acetyl coA by pyruvate dehydrogenase IN MITOCHONDRIA

Question 13

how does acetyl coA get from the mitochondria to the cytosol for fatty acid synthesis

Answer 13

acetyl coA is converted to citrate
citrate goes out of mitochondria into cytosol
citrate converted back to acetyl coA

Question 14

Malonyl coA’s function in fatty acid synthesis

Answer 14

adds 2 carbons in FA elongation

Question 15

3 essential fatty acids

Answer 15

linoleic acid
alpha linolenic acid
arachidonic acid

Question 16

insulin _____ fatty acid synthesis

Answer 16

STIMULATES