Exam 2 Flashcards
microtubules
tubulin dimers of alpha and beta tubulin –> 13 protofilaments
tubulin is a
GTPase
+/- end of microtubules
+ end: high exchange rate of alpha and beta tubulin - end: static end
functions of Microtubules
mitotic spindle, organelle transport, cell shape
dynamic instability in microtubules
catastrophe = shrink, rescue = grow
microtubule associated motor proteins
- dyenin (- end directed) 2. kinesin (+ end directed)
centrosome
MT ognizing center/site of nucleation (genesis of cytoskeletal polymer) - uses gamma tubulin
basal body
MT organizing center for cilia and flagella
axonemone
9+2 microtubule structure of cilia and flagella *dyenin drives axenemal activity
immotile cilia syndrome
defect in anexome structure –> obtrusive lung disease, male sterility
kartagene’s syndrome
situs inversus and immotile cilia cyndrome
lissencephaly
mutations in microtubule proteins HS1 and doublecortin
Charcot-Marie-Tooth
kinesin mutation
microfilaments
nonhollow polymers of actin with ATPase activity
ends of microfilaments are called
barbed end (+) and pointed end (-) **myosin moves towards the + end
hereditary spherocytosis
RBC forms spherocyte because weak binding of spectrin to band 4
epidermis bullose simplex
intermediate filament disorder - keratin mutation in basal skin cell layer, results in very sensitive skin that easily is torn
progeria (hutchinson gilford syndrome)
intermediate filament disorder - “fast again” mutation in nuclear lamin protein autosomal dominant
Most cells in our bodies are in what phase?
G0
CDKs control cell cycle progression by activating
cyclins
p54
induces cell cycle arrest by inhibiting CDKs - can also trigger apoptosis
terminally differentiated cells
have permanently exited the cell cycle (so differentiated that they can’t re-enter)
totipotent
cells from the fertilized egg/morula; can become any cell type
pluripotent
cells from the blastula –> can be ecotoderm, mesoderm, and endoderm
multipotent
ex. progenitor hematopoetic cells