Regional Pneumonia Flashcards
Regional Pneumonia
Fungal infection most common in immunocomp. Dimorphic with hypha at 25C and yeast at 31C
Histoplasma Capsulatum Clin
Histoplasmosis (atyp pneu) with lung cavitations which once heal calcify leading to coin lesions. Can be chronic with underlying disease present, can disseminate to liver, spleen, marrow, lymph.
Histoplasma Capsulatum path
Inhaled as hyphae (bird/bat guano), periph blood shows monocytes with intracell yeast. (lung = alv macrophages)
Histoplasma Capsulatum RF
Ohio and mississippi have increased incidence
Histoplasma Capsulatum Tx
anti-fungals
Histoplasma Capsulatum Diag
Culture for dimorphic, serology, HPA, Urine Ag, CXR lesions, BAL biopsy, skin test for epidemiology
Blastomyces Dermatitidis Clin
Blastomycosis (typ pneumonia) with dissemination. Low lobar consolidation, extra pulmonary lesions (include skin ulcerated granulomas).
Blastomyces Dermatitidis RF
South Central and East USA. Wooded Areas
Blastomyces Dermatitidis Char
Dimorphic EC fungi, broad based budding yeast with capsule. Enviromental is a mold with septated hyphae
Blastomyces Dermatitidis Diag
KOH or Ag to BAD1
Coccidiodes Immitis Clinical
Coccidiomycosis (atyp pneu) with lung cavitations and erythema nodosum or multiform. Arthritis.
Coccidiodes Immitis Erythema Nodosum
tender nodules with organism on skin
Coccidiodes Immitis Erythema multiform
Type 4 HSR
Coccidiodes Immitis path
Environment as mold with hyphae - fragment to erthrocanididia to lungs to spherules = spores
Coccidiodes Immitis Char
Dimorphic extracell spherule fungus leads to T cell reaction = granuloma
