Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Med Micro Block 2 > Influenza > Flashcards

Influenza Flashcards

1
Q

Orthomyxoviridae Clinical

A

Atypical pneu and Influenza. Fever above 101.5, myalgia, dyspnea.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Orthomyxoviridae RF

A

65 years or older, children, Chronic illness, Immunocomp

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Orthomyxoviridae Pathogenesis

A

Local URT infections kills mucous secreting cells and cilia. NA cleaves mucous allowing more cell infections. Viremia and subsequent cytokine release leads to myalgia. If to lungs, causes desquamination of epithelium in bronchi and alveoli leading to susceptibility to bact pneumonia.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Orthomyxoviridae Char

A

Enveloped segmental neg sense RNA (8 segments). A = epidemic/ pandemic; B = major outbreaks; C=mild

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Orthomyxoviridae VF

A

HA (16) binds to cell surface receptor to initiate infiltration
NA (9) cleaves N-acetyl neuraminic acid to release virus and nucleus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Orthomyxoviridae Diag

A

Cell culture, nasal swab for rapid Ag detect (EIA and DFA), serum abs by HAI and EIA for typing. CXR for interstitial pneumonia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Orthomyxoviridae Tx

A

A = Admantin antivirals = Amantidine and Rimantidin: viral M2 ion channel inhib leading to loss of coat

A/B = Tamiflu (oseltamivir) = NA inhib

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Orthomyxoviridae VCCN

A

Inact vccn - intra musc, low IgG titers induced - short

Live attenuated = Flumist for non pregnant. Induce IgA via temp sensitive A and B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Orthomyxoviridae Ag shift

A

Reassortment of segmented genome ( HA and NA change). M1 and M2 conserved

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Orthomyxoviridae Ag drift

A

Point mutation in H and N leads to pandemics (new strains)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Avian Influenza

A

Birds carry all different types of enveloped proteins (receptor = alpha-2,3 Sialic Acid)

1997 - H5N1
2014 - H7N9 leading to resp fail, resistant to admantadine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Coronaviridae: SARS-COV Clin

A

Acute resp distress with atyp pneumonia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Coronaviridae: SARS-COV Char

A

enveloped ss pos sense RNA, path linked to ACE2 receptor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Coronaviridae: SARS-COV Tx

A

none

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Coronaviridae: SARS-COV Prev

A

Isolation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Coronaviridae: MERS-COV Clin

A

Acute resp illness with renal fail and pericarditis

17
Q

Coronaviridae: MERS-COV Char

A

Enveloped pos ss sense RNA

18
Q

Coronaviridae: MERS-COV Receptor

A

dipeptidyl peptide 4 (DP4) - CD26 to enter cells

19
Q

Coronaviridae: MERS-COV Diag

A

PCR

20
Q

Coronaviridae: MERS-COV Res

A

camels, Middle East

21
Q

Coronaviridae: MERS-COV Tx

A

Supportive

Med Micro Block 2 (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions