Pharyngitis

Question 1

General Info

Answer 1

90% viral
Bacterial has exudate
Viral no exudate
With general erythema

Question 2

Adenovirus Clinical

Answer 2

Primary cause of pharyngitis, with fever, erythema throat

Can cause Pharyngoconjunctival Fever with watery/Sticky conjunctival exudate

Question 3

Adenovirus Char

Answer 3

dsDNA, no envelope

Question 4

Adenovirus Trans

Answer 4

Resp droplets and contaminated water and fomites

Question 5

Adenovirus Diag

Answer 5

Clinical and Ag detection

Question 6

Picornaviridae Clinical

Answer 6

Pharyngitis/Herpengina with fever, erythema throat, ulcerative eruptions on post esophagus

Question 7

Picornaviridae Char

Answer 7

Coxsackie A16

Pos sense ssRNA, no envelope

Question 8

Picornaviridae Trans

Answer 8

Fecal oral/ Respo droplets

Question 9

Streptococcus Pyogenes Clinical

Answer 9

Pharyngitis with exudate and Petechia

Question 10

Streptococcus Pyogenes Comp/Seq

Answer 10

Rheumatic fever and glomerulonephritis

Question 11

Streptococcus Pyogenes Char

Answer 11

Gram pos cocci

Question 12

Streptococcus Pyogenes VF

Answer 12

M proteins, capsule, streptokinase, DNAse, streptolysin

Question 13

Streptococcus Pyogenes Diag

Answer 13

Beta hemolytic, catalase neg, GAS, bacitracin sensitive

Rapid Strep test (anti-enzyme, low sense)

Question 14

Streptococcus Pyogenes Tx

Answer 14

Beta lactams (used for rheumatic but not glom)

Question 15

Acute Glomerulonephritis

Answer 15

Immunologic mechanism causing dmg to basement memb, mesangium and cap epi. Leads to sudden onset of hematuria, impaired renal fx, proteinuria, hypertension.

Question 16

Acute Glomerulonephritis Causes

Answer 16

Strep spp. group A
Serotype 12 - post strep neph due to URT, winter
Serotype 40 - post strep neph due to skin, summer and fall in south

Question 17

Rheumatic Fever

Answer 17

Autoimmune disorder (bact cleared) rxn to GAS pharyngitis. Symptoms appear 2-3 wks post inf with inflamm changes leading to carditis, arthritis, bv and subcut tissue inflamm. Assoc with fever and rash

Question 18

Rheumatic fever diag

Answer 18

Jones Criteria. Major = carditis, chorea (aberrant mvmt), erthema margintum (macular ring rash) subcut nodules

Evidence of prior GAS inf = Increased anti-streptolysin O, pos throat culture, pos rapid GAS Ag test, recent scarlet fever

Question 19

Fusobacterium Necrophorum Clinical

Answer 19

non exudate pharyngitis, complication leads to Lemierre syndrome

Question 20

Fusobacterium Necrophorum Char

Answer 20

Anaerobic gram neg rod, norm oral flora

Question 21

Arcanobacterium Haemolyticum Clin

Answer 21

Exudate pharyngitis, pseudomembrane dieases with maculopapular rash on extremities

Question 22

Arcanobacterium Haemolyticum Char

Answer 22

Aerobic non spore gram pos rod

Gelatinase pos

Question 23

Corynebacterium Diptheriae Clin

Answer 23

Pharyngitis and pseudomemb, fever, cervical lymphoadenopathy, myocarditis, neuritis

Question 24

Corynebacterium Diptheriae Char

Answer 24

Gram pos rod

Question 25

Corynebacterium Diptheriae VF

Answer 25

Diptheria toxon on lys phage. Inhibits protein synth via ADP ribosylation and inact of EF2. Regulated by DTxR (FE dependent repressor protein) decreased Iron = decreased DTxR = Increased toxin

Question 26

Corynebacterium Diptheriae Diag

Answer 26

Tellurite Agar with cysteine (gray/blue colonies)
Toxin assay (ELEK)
PCR

Question 27

Corynebacterium Diptheriae VCCN

Answer 27

DPT toxoid vaccine with boosters

Question 28

Paramyxovirus Fam Clinical

Answer 28

Mumps (swollen parotid and sore throat), orchitis, oophoritis, pancreatitis

Question 29

Paramyxovirus Fam Char

Answer 29

neg sense ssRNA with envelope

Question 30

Paramyxovirus Fam VF

Answer 30

F - fusion peplomer; induces syncytia

H - Hemaglutinin peplomer

Question 31

Paramyxovirus Fam Diag

Answer 31

Clinical, serology/HAI, RT-PCR

Question 32

Paramyxovirus Fam Vccn

Answer 32

MMR (live attenuated)