Regenerative therapies

Question 1

What do anti-Nogo-A antibodies cause in rats?

Answer 1

Increase axon regeneration

Question 2

What happens if you inhibit MAG OMgp and Nogo-A?

Answer 2

No regeneration at all

Question 3

What does chrondroitinase ABC do?

Answer 3

It’s an enzyme that digest glycosaminoglycan CSPGs side chains.

Question 4

What happened to Rodents treated with Chrondroitin ABC?

Answer 4

Fibres were able to regrow around the lesion better.

Question 5

Name 5 regeneration treatments for neurons?

Answer 5

-bridge the glial scar
-permissive substrate
-cell replacement
-growth factors
-remyelination

Question 6

Names the commonly transplanted cell types in the brain:

Answer 6

Schwann cells
Olfactory ensheathing cells (OECs)
Induced pluripotent stem cells (IPSCs)
Embryonic stem cells (ESCs)

Question 7

What type of neurons regenerate through an animals life time?

Answer 7

Olfactory neurons

Question 8

What cell type can grow through the glial scar?

Answer 8

Olfactory neurons can phagocytise debris allowing axons to grow through glial scars