Amyloid beta & interactions with TAU Flashcards
Name 4 alzheimers risk factors?
Age
lifestyle
gentic variation
mutations
prior syndromes (high bp)
is removing Amyloid plaques in advanced AD enough to save cognition?
no it isnt
In the alzhiemers Amyloid beta trials, what happened in active immunisation?
There were severe side-effects
Due to the reaction of active immunisation trials in AD, what is suggested?
Trials using passive immunisation such as ready made antibodies.
What experiment was used to test the mouse models of AD?
The morris water maze
What is the morris water maze?
Its a space of white water with one platform, the mouse cant see. But the mouse should increase the speed it finds the platform with each test, using memory.
What does the Morris water maze test?
The last step is to take away the platform and track where it searches. trsting spatial and acquisitional memory
What happens to neurons with Amyloid beta?
they die as amyloid beta is toxic to neurons. Can die within hours or days.
What can amyloid beta do to neurons?
-Kill the neuron
-decrease dendritic spine density
-impair synaptic plasticity
what is synaptic plasticity?
Activity dependent change in neuronal plasrticity that effects synaptic strength
what is dendritic spine density?
Spines are protusions on dendrites that recieve glutaminergic transmissions,they grow as they get stronger. Thought to be the locus of memory.
How can you test for AD?
hermogenise and electrophoresis of neurons, onl DS and AD have Amyloid beta band.
what is required to inhibit synaptic plasticity of hippocampal synapses?
TAU and Amyloid beta
what evidence shows amyloid beta as a driver of alzheimers?
-clear genetic link between Amyloid beta production and AD
-similar pathological progressions
-Amyloid beta imapirs synaptic transmission in cell culture and mouse models
Would prevention of amyloid beta cure AD?
No, amyloid beta is not the only driver of AD
