Regenerative Medicine Flashcards
Can you regulate emerging technologies in advance?
No - case-by-case approach
What is regenerative medicine?
diverse set of technologies that have the opportunity to transform health, to have a major impact on human body to repair & restore our bodies to normal functioning health
What are regenerative medicine treatments founded on?
Concept of producing new cells to replace malfunctioning or damaged cells as a vehicle to treat disease & injury
What are 3 ways tissue engineering perform by?
Promoting tissue regeneration in situ in isolation
Promoting tissue regen. in situ in combination with chemical/cellular agents
Producing new tissue in vitro or ex vivo & implanting it
What are 5 things that enable technolgies in regen. medicine?
Scientific understanding
Precision engineering
Next-Gen biomaterials
Cellular sources & molecular techniques
3D printing
What are challenges of regen. medicine?
Immunogenicity
Regulation
False-dawns
Design & execution of trails
Potential adverse effects
What are 3 components of tissue engineering?
Cells
Scaffolds
Biological factors
What do undifferentiated progenitor cells have the ability to do?
Proliferate & differentiate into various tissues captivated by biomedical scientists
What are 2 example of stem cells?
ESCs
MSCs
What type of cell is present in the zygote?
Totipotent - give rise to all cells types of body & extra-embryionic tissues
What are pluripotent cells capable of?
Giving rise to all cell types of body
What are multipotent cells capable of?
Giving rise of all cell types in a particular organ
What cell is not cpabale of giving rise to other cell types?
Nullipotent
What are 4 downfalls of ESCs?
Ethical issues
Tumour forming
Differentiation control & manipulation
Immunogenic potential
What do adult stem cells (iPSCs) eliminate?
Ethical issues
What is an additonal downfall of iPSCs?
In vivo delivery & retention
What are 4 bioscaffolds?
Metals
Ceramics
Synthetic polymers (PEG)
Biopolymers (collagen, hyaluronan)
In the US what is the stats for being at risk for CKD?
1 in 3 (73, 000, 000)
Whats the only supportive treatment for CKD?
Dialysis & transplant
What is the biggest cause of CKD?
Diabetes
What are 4 regen. medicine approaches for CKD?
- MSCs as disease-modulating agents
- Kidney-derived ‘adult’ stem cells for repair & regeneration of damaged kidney tissue
- Re-programmed ESCs or induced pluripotent stem cells to regenerate kidneys
- Engineering of new kidneys by seeding adult and/or reprogrammed pluripotent stem cells into a matrix
What are 2 future approaches?
Synegry between regenerative therapies & medical devices
Bioartificial kidney
What type of medicine is the biggest challenge for toxicology?
nanomedicine
