Regenerative Medicine

Question 1

Can you regulate emerging technologies in advance?

Answer 1

No - case-by-case approach

Question 2

What is regenerative medicine?

Answer 2

diverse set of technologies that have the opportunity to transform health, to have a major impact on human body to repair & restore our bodies to normal functioning health

Question 3

What are regenerative medicine treatments founded on?

Answer 3

Concept of producing new cells to replace malfunctioning or damaged cells as a vehicle to treat disease & injury

Question 4

What are 3 ways tissue engineering perform by?

Answer 4

Promoting tissue regeneration in situ in isolation
Promoting tissue regen. in situ in combination with chemical/cellular agents
Producing new tissue in vitro or ex vivo & implanting it

Question 5

What are 5 things that enable technolgies in regen. medicine?

Answer 5

Scientific understanding
Precision engineering
Next-Gen biomaterials
Cellular sources & molecular techniques
3D printing

Question 6

What are challenges of regen. medicine?

Answer 6

Immunogenicity
Regulation
False-dawns
Design & execution of trails
Potential adverse effects

Question 7

What are 3 components of tissue engineering?

Answer 7

Cells
Scaffolds
Biological factors

Question 8

What do undifferentiated progenitor cells have the ability to do?

Answer 8

Proliferate & differentiate into various tissues captivated by biomedical scientists

Question 9

What are 2 example of stem cells?

Answer 9

ESCs
MSCs

Question 10

What type of cell is present in the zygote?

Answer 10

Totipotent - give rise to all cells types of body & extra-embryionic tissues

Question 11

What are pluripotent cells capable of?

Answer 11

Giving rise to all cell types of body

Question 12

What are multipotent cells capable of?

Answer 12

Giving rise of all cell types in a particular organ

Question 13

What cell is not cpabale of giving rise to other cell types?

Answer 13

Nullipotent

Question 14

What are 4 downfalls of ESCs?

Answer 14

Ethical issues
Tumour forming
Differentiation control & manipulation
Immunogenic potential

Question 15

What do adult stem cells (iPSCs) eliminate?

Answer 15

Ethical issues

Question 16

What is an additonal downfall of iPSCs?

Answer 16

In vivo delivery & retention

Question 17

What are 4 bioscaffolds?

Answer 17

Metals
Ceramics
Synthetic polymers (PEG)
Biopolymers (collagen, hyaluronan)

Question 18

In the US what is the stats for being at risk for CKD?

Answer 18

1 in 3 (73, 000, 000)

Question 19

Whats the only supportive treatment for CKD?

Answer 19

Dialysis & transplant

Question 20

What is the biggest cause of CKD?

Answer 20

Diabetes

Question 21

What are 4 regen. medicine approaches for CKD?

Answer 21

1. MSCs as disease-modulating agents
2. Kidney-derived ‘adult’ stem cells for repair & regeneration of damaged kidney tissue
3. Re-programmed ESCs or induced pluripotent stem cells to regenerate kidneys
4. Engineering of new kidneys by seeding adult and/or reprogrammed pluripotent stem cells into a matrix

Question 22

What are 2 future approaches?

Answer 22

Synegry between regenerative therapies & medical devices
Bioartificial kidney

Question 23

What type of medicine is the biggest challenge for toxicology?

Answer 23

nanomedicine