P4 and Systems Medicine Flashcards
What is medical care designed to optimize?
Efficiency or therapeutic benefit for particular groups of patients especially by using genetic or molecular profiling
What is precision medicine?
Approach that takes into account individual variability in genes, environment & lifestyle
What information does precision medicine use?
Person’s genes, proteins, environment to prevent, diagnose & treat disease
What will NCI do in the precision medicine intiative?
Design & testing of effective, tailored treatments for cancer by expanding genetically based clinical cancer trails
What does personalised medicine use in cancer?
Specific info about the person’s tumour to diagnose, treat & make a prognosis
What is systems mediicne?
Interdisciplinary field that looks at systems in the body as part of an integrated whole, incorporating biochemical, physiological & environment interactions
What type of modelling does systems modelling use?
mathematical & computational
What does a model represent?
System that allows for investigation of the properties of the system & prediction of future outcomes
What 4 things do models allow us to do?
Investigate properties of a system
find salient features of a system
understand complex realities
predict future outcomes
Define systems pharmacology.
Application of systems biology principles to field of pharmacology
What is P4 medicine?
Predict
Prevent
Personalize
Participate
What are some wearable biosensors for healthcare monitoring?
Smart con tact lenses (glucose)
Mouthguard (uric acid)
Eyeglasses (lactate, glucose)
Microfluidic (lactate, glucose)
What was the P100 study?
Wellness study of 108 individuals using personal, dense, dynamic data clouds
What did the P100 results show?
Measurement of personal data clouds over time can improve understanding of health & disease like eg early transitions to disease states
What is the VPH institute?
Methodological & technological framework that will enable collaborative investigation of human body as a single complex system
What is Avicenna Alliance?
Predictive or ‘in silico medicine’ using computer modelling & simulation for disease diagnosis, treatment & prevention & product development
