Red Cells Flashcards
What is the pathway of erythrocyte development?
Stem cell –> haemocystoblast –> proerythroblast –> early erythroblast –> late erythroblast –> normoblast –> reticulocyte –> erythroblast
What occurs between early erythroblast and late erythroblast?
Ribosome synthesis
What occurs between late erythroblast and normoblast?
Haemoglobin accumulation
What happens between reticulocyte and erythrocytes?
Ejection of nucleus
What metals are used in making a blood cell?
Iron
Magnesium
Cobalt
Copper
What vitamins are used in making a blood cell?
B12
Thiamine
Folic acid
B6, C, E
What else is used in making a RBC?
Hormones
Amino acids
What system breaks down RBCs?
Reticuloendothelial system
What is the reticuloendothelial system?
Macrophages in major organs
- Spleen
- Liver
- Lungs
What is recycled in haemoglobin?
Iron
Globin chains
How is iron excreted by the reticuloendothelial system?
Converted to bilverdin (neutralised)
Excreted as bilirubin
