Red Blood Cells, Anemia and Polycythemia Flashcards
What is the volume of blood in the average adult?
~5.5 L
RBC do not have what important organelles?
- Nucleus
- Mitochondria
Hematocrit
%RBC/Volume
Normal Hematocrit in Males
40-50%
Normal Hematocrit in Females
36-47%
Organs that produce RBC in adults
Bone Marrow
Organs that produce RBC in the fetus
Yolk, PAS/AGM, Liver, Blood, Thymus bone marrow
Life span of the RBC
120 Days
Life span of the RBC in sickle cell anemia
10-15 days
Name of the primary stem cell for blood components
Pluripotent Hematopoietic Stem cell (PHSC)
Name the two important progenitor cells PHSC divides into
- Common Myeloid Progenitor
- Common Lymphoid Progenitor
What is the first recognizable cell in the genesis of RBC
Proerythrocyte
What is the name of immature RBCs?
Reticulocyte
-retain residual RNA/Mitochondria
How long does it take a reticulocyte to mature into a mature RBC?
2 days
When are elevated counts of reticulocytes found in the blood?
In patients who’s condition requires accelerated RBC production (bleeding)
Erythropoetin
Hormonal control of RBC production
What organs release EPO and to what stimuli?
Kidneys, and to hypoxia.
-Kidneys sense decreased oxygen levels and release erythropoetin that act on the progenitor cells in bone marrow to increase production of RBC