rectal delivery

Question 1

when is rectal delivery given

Answer 1

Rectal delivery is given when:

- Oral admin is problematic 
- Unconscious, nauseous and postoperative 
- Very young , very old
- Mentally disturbed patients 

- Drug is not suitable for oral delivery 
	○ Gastrointestinal side effects 
	○ Instability of drug at PH or in  GIT
	○ Taste  
- Locally acting drug 
	○ Pain/itching due to haemorrhoids Local anaesthetic, microbicides , anti-inflammatory

Question 2

physiological features of the rectum

Answer 2

-part of the colon

normally rectum is empty

Question 3

what are the different forms for rectal admin

Answer 3

suppositories - dissolves or melts and absorbed into the blood strean
tablets 
capsules 
ointment 
enema

Question 4

requirements to suppository bases -

Answer 4

-melt/ dissolve just below body temperature
-solidify quickly after melting
-can easily be moulded
be chemically stable even when molten
release API readily
easy to handle
non-toxic and non irritant

Question 5

what are the classification of the bases

Answer 5

• fatty bases

- hydrophilic bases - can draw water from rectal epithelium and cause dehydration