oromucosal

Question 1

what are the 3 types of oromuscosal delivery

Answer 1

Buccal drug delivery:
○ Administered via the mucosal membranes lining the cheeks (buccal mucosa)

• Sublingual drug delivery:
  ○ Administered via the mucosal membranes lining the floor of the mouth
• Gingival delivery:
  Drug is delivered through the gum

Question 2

what is the differences between buccal and sublingual drug delivery

Answer 2

Buccal has low permeability and slow absorption rate as its thicker, expanse of smooth muscle - more useful for sustained drug delivery

sublingual - faster absorption and higher permeability as its less thick and its always washed out by saliva - short delivery

Question 3

what are the physiological factors in the mouth which could effect dosage form

Answer 3

saliva - for lubrication, digestion of food (amalayse) protection against bacteria and speech
remove small amounts of dosage form = less effect
PH

Question 4

what is pH hypothesis

Answer 4

unionised molecules will get absorbed by any biological membranes much better than ionised molecules

Question 5

molecule polarity relating to log P

Answer 5

Determine the hydrophobic/hydrophilic properties
Higher the log P - the more hydrophobic the molecules is
less polar molecules - more capable of being absorbed

Question 6

how does molecular weight effect absorption

Answer 6

smaller the mwt - easier the absorption by the membrane

Question 7

types of formulation for buccal delivery

Answer 7

• buccal tablets
• buccal patches/films
• lozenge
• mouthwashes

Question 8

advantages and disadvantages of buccal

Answer 8

A: avoid exposure to GI 
bypass the liver 
direct access to systemic circulation 
rapid absorption 
ease of administration 

D : small absorptive surface area 
less permeable than Large intestine 
salivation 
taste of the drug 
avoidance of swallowinggg